Extract AES-PCs from recorded pathway-subsets of a mass spectrometry or bio-assay data frame

Given a clean OmicsPath object (cleaned by the IntersectOmicsPwyCollct function), extract the first principal components (PCs) from each pathway with features recorded in the assay design matrix.

ExtractAESPCs(
  object,
  numPCs = 1,
  parallel = FALSE,
  numCores = NULL,
  standardPCA = FALSE,
  ...
)

# S4 method for OmicsPathway
ExtractAESPCs(
  object,
  numPCs = 1,
  parallel = FALSE,
  numCores = NULL,
  standardPCA = FALSE,
  ...
)

Arguments

object	An object of class OmicsPathway.
numPCs	The number of PCs to extract from each pathway. Defaults to 1.
parallel	Should the computation be completed in parallel? Defaults to FALSE.
numCores	If parallel = TRUE, how many cores should be used for computation? Internally defaults to the number of available cores minus 2.
standardPCA	Should the function return the AES-PCA PCs and loadings (FALSE) or the standard PCA PCs and loadings (TRUE)? Defaults to FALSE.
...	Dots for additional internal arguments (currently unused).

Value

Two lists of matrices: PCs and loadings. Each element of both lists will be named by its pathway. The elements of the PCs list will be \(N \times\) numPCs matrices containing the first numPCs principal components from each pathway. The elements of the loadings list will be numPCs \(\times p\) projection matrices containing the loadings corresponding to the first numPCs principal components from each pathway. See "Details" for more information.

Details

This function takes in a data frame with named columns and a pathway list as an OmicsPathway object which has had unrecorded -Omes removed from the corresponding pathway collection by the IntersectOmicsPwyCollct function. This function will then iterate over the list of pathways, extracting columns from the assay design matrix which match the genes listed in that pathway as a sub-matrix (as a data.frame object). This function will then call the aespca on each data frame in the list of pathway-specific design matrices, extracting the first numPCs AES principal components from each pathway data frame. These PC matrices are returned as a named list.

NOTE: some genes will be included in more than one pathway, so these pathways are not mutually exclusive. Further note that there may be many genes in the assay design matrix that are not included in the pathways, so these will not be extracted to the list. It is then vitally important to use either a very broad and generic list of pathways or a pathways list that is compatible to the assay data supplied.

See also

CreateOmicsPath; aespca IntersectOmicsPwyCollct

Examples

  # DO NOT CALL THIS FUNCTION DIRECTLY.
  # Use AESPCA_pVals() instead


  ###  Load the Example Data  ###
  data("colonSurv_df")
  data("colon_pathwayCollection")

  ###  Create an OmicsSurv Object  ###
  colon_Omics <- CreateOmics(
    assayData_df = colonSurv_df[, -(2:3)],
    pathwayCollection_ls = colon_pathwayCollection,
    response = colonSurv_df[, 1:3],
    respType = "surv"
  )
#> 
#>   ======  Creating object of class OmicsSurv  =======
#> The input pathway database included 676 unique features.
#> The input assay dataset included 656 features.
#> Only pathways with at least 3 or more features included in the assay dataset are
#>   tested (specified by minPathSize parameter). There are 15 pathways which meet
#>   this criterion.
#> Because pathwayPCA is a self-contained test (PMID: 17303618), only features in
#>   both assay data and pathway database are considered for analysis. There are 615
#>   such features shared by the input assay and pathway database.

  ###  Extract Pathway PCs and Loadings  ###
  ExtractAESPCs(
    object = colon_Omics,
    parallel = TRUE,
    numCores = 2
  )
#> Initializing Computing Cluster: 
#> DONE
#> Extracting Pathway PCs in Parallel: 
#> DONE
#> $PCs
#> $PCs$pathway3
#>               V1
#> 1   -1.333801785
#> 2   -5.308031692
#> 3    0.651110109
#> 4   -3.256720613
#> 5   -1.440621512
#> 6    0.866728919
#> 7    0.987022863
#> 8   -1.118117094
#> 9   -0.838802411
#> 10   2.628377593
#> 11   3.375707648
#> 12   0.660722461
#> 13  -3.803726722
#> 14  -0.825989895
#> 15   0.977042089
#> 16   0.302439851
#> 17   0.624727450
#> 18  -1.276621772
#> 19  -1.849622550
#> 20   1.873973391
#> 21   0.459734667
#> 22   2.230144032
#> 23  -0.096409514
#> 24   0.598075524
#> 25   0.852435785
#> 26  -0.943272786
#> 27   1.629366705
#> 28  -1.732461456
#> 29  -0.222308428
#> 30   2.325359094
#> 31   2.803890671
#> 32   1.597921174
#> 33   1.696202963
#> 34   5.007666758
#> 35   0.205769381
#> 36   1.645899485
#> 37  -1.879901437
#> 38   0.008555523
#> 39  -0.191474190
#> 40   3.319925707
#> 41   0.823589591
#> 42  -0.895305425
#> 43   1.455247315
#> 44  -0.197407341
#> 45   1.246618808
#> 46   0.011795706
#> 47   1.488710594
#> 48  -3.296163145
#> 49  -1.094163491
#> 50  -8.285732547
#> 51  -0.811023947
#> 52   0.168527412
#> 53  -3.411984215
#> 54   1.195538118
#> 55   1.173793168
#> 56   0.081545817
#> 57  -2.546582670
#> 58   1.288904508
#> 59  -1.754787546
#> 60  -2.423411847
#> 61  -0.879078459
#> 62   0.341471650
#> 63  -0.126353293
#> 64   0.335979515
#> 65  -1.580502919
#> 66   0.911941062
#> 67  -0.718195064
#> 68   0.725633290
#> 69   0.916012985
#> 70  -0.346872825
#> 71  -1.116671442
#> 72  -1.800183461
#> 73   1.573538419
#> 74   0.606522739
#> 75  -0.896439095
#> 76   1.104005689
#> 77  -3.650445357
#> 78  -0.500681121
#> 79   0.185046905
#> 80   0.869536439
#> 81   1.557583440
#> 82  -0.061876934
#> 83   1.964376336
#> 84   1.066699215
#> 85   0.842662116
#> 86   2.107821075
#> 87  -2.923368531
#> 88  -1.328990485
#> 89  -4.879988973
#> 90   1.039166376
#> 91   0.900109688
#> 92  -0.044937225
#> 93  -1.534469112
#> 94   2.171274781
#> 95  -0.851143591
#> 96   2.359744726
#> 97   2.659801170
#> 98   0.276938086
#> 99  -0.075719868
#> 100  1.012384205
#> 101  1.457939117
#> 102  0.133132070
#> 103  1.134040198
#> 104  0.615393704
#> 105  3.267791383
#> 106  0.347609623
#> 107 -0.253510985
#> 108  0.009349748
#> 109 -1.343744825
#> 110  2.079198810
#> 111  0.135548659
#> 112  1.520510825
#> 113  1.450685703
#> 114 -0.041691687
#> 115  2.208038803
#> 116 -1.109922718
#> 117  1.190289306
#> 118  1.003165123
#> 119  3.568739449
#> 120  0.245346241
#> 121 -0.384422166
#> 122 -0.028519467
#> 123 -0.418856862
#> 124 -1.497240065
#> 125 -1.960009837
#> 126  0.151308992
#> 127 -0.067642523
#> 128 -0.858518851
#> 129  0.747984848
#> 130 -0.931074465
#> 131  0.157306882
#> 132  3.325122907
#> 133 -1.525585474
#> 134 -1.936843314
#> 135 -0.008960219
#> 136  2.280335817
#> 137  2.895739002
#> 138  2.434085757
#> 139  1.923968057
#> 140  1.466261920
#> 141 -1.054905245
#> 142  0.886371406
#> 143  0.587953256
#> 144 -0.986181961
#> 145 -1.514266056
#> 146  2.682584593
#> 147 -1.188593764
#> 148 -2.650652741
#> 149  2.736852378
#> 150  1.347170781
#> 151  0.071679406
#> 152 -1.340701304
#> 153 -1.016216079
#> 154 -1.264544593
#> 155 -0.148269525
#> 156  1.157351082
#> 157  1.797466635
#> 158  1.275781976
#> 159  0.470509997
#> 160  1.021114679
#> 161 -5.098583462
#> 162  0.699265505
#> 163 -0.770003500
#> 164 -1.316808134
#> 165  1.442652082
#> 166 -1.049486566
#> 167 -0.349875975
#> 168  0.555547184
#> 169  0.288362241
#> 170 -0.598796287
#> 171  3.358724895
#> 172  2.633898791
#> 173 -2.504267258
#> 174 -0.073769211
#> 175 -0.872376709
#> 176 -1.363215168
#> 177  1.554154674
#> 178 -3.425780329
#> 179 -3.411832540
#> 180  2.044004167
#> 181 -5.506334926
#> 182  1.087704352
#> 183  0.141528165
#> 184 -9.866643747
#> 185  1.098754188
#> 186 -0.860426403
#> 187 -1.715993945
#> 188  1.668968047
#> 189 -0.219536220
#> 190  0.085011603
#> 191 -2.879246374
#> 192 -1.866345376
#> 193  0.949404203
#> 194 -0.482794563
#> 195  0.204235784
#> 196  0.503950240
#> 197  0.354511334
#> 198 -0.278301895
#> 199 -0.590581934
#> 200 -3.476981292
#> 201 -1.870597173
#> 202  1.618730421
#> 203  1.461169252
#> 204 -3.657652400
#> 205 -0.720905971
#> 206  0.572993408
#> 207  1.859415799
#> 208  1.634361812
#> 209 -1.452208722
#> 210  1.531454653
#> 211 -0.786172178
#> 212  0.464431757
#> 213 -0.325901135
#> 214  1.177768925
#> 215  0.516343145
#> 216  2.420036160
#> 217  3.262151217
#> 218 -0.653295455
#> 219  0.024891774
#> 220 -1.008395650
#> 221 -1.315335730
#> 222  0.313042731
#> 223  0.568879299
#> 224  2.500849111
#> 225 -0.966052952
#> 226  0.823788664
#> 227 -1.163484283
#> 228  1.347720716
#> 229 -1.043961208
#> 230 -0.767160759
#> 231 -3.707971158
#> 232 -1.522908748
#> 233  0.861219871
#> 234  1.894578385
#> 235 -3.936315608
#> 236 -3.091294244
#> 237  3.535414599
#> 238 -2.313961415
#> 239  1.490347064
#> 240 -0.327538176
#> 241 -2.622142989
#> 242  2.027297251
#> 243  3.304878028
#> 244 -0.480738817
#> 245  0.635609274
#> 246 -1.688536143
#> 247  1.054917499
#> 248  0.296735990
#> 249  3.973024396
#> 250  0.263972662
#> 
#> $PCs$pathway60
#>                V1
#> 1    2.8971711901
#> 2    5.5726897890
#> 3   -1.9938719956
#> 4    7.2121395628
#> 5    5.8248562822
#> 6    0.8743486109
#> 7    3.7491582328
#> 8    0.1256249085
#> 9   -1.4052008060
#> 10   0.9214060196
#> 11  -1.9200777913
#> 12  -1.7880907845
#> 13  -0.0862706811
#> 14  -2.4862309050
#> 15   0.9834866471
#> 16  -0.1339940200
#> 17  -0.2414446431
#> 18   1.2676008980
#> 19   1.4621682170
#> 20  -3.1833252762
#> 21   0.0476218302
#> 22   1.3137224949
#> 23  -3.0338308531
#> 24   0.5726472025
#> 25   2.2721397277
#> 26  -1.3781561957
#> 27   3.7283084965
#> 28  -0.2561831635
#> 29   1.4312510417
#> 30  -1.3290077364
#> 31  -0.5167934685
#> 32  -0.2625309477
#> 33  -0.3168382080
#> 34   2.5973560809
#> 35   1.1856634571
#> 36  -1.2988937156
#> 37   3.5018474675
#> 38  -3.0591544289
#> 39  -1.4658864157
#> 40  -4.7089915432
#> 41  -0.6776705490
#> 42   2.6925104231
#> 43  -0.9263504071
#> 44  -0.6440993583
#> 45  -1.2376653382
#> 46  -2.1134084128
#> 47  -0.2426207471
#> 48   1.9360830870
#> 49  -1.8112649835
#> 50  -0.6633198659
#> 51  -0.3970327687
#> 52  -0.3150199332
#> 53  -3.2890287426
#> 54  -2.4007348288
#> 55  -1.8755340094
#> 56  -0.4506678251
#> 57   2.2181500333
#> 58  -0.0304896943
#> 59   0.1299646353
#> 60   1.7837299100
#> 61  -2.1562235800
#> 62   0.0007937454
#> 63   0.1445470390
#> 64  -0.5368462422
#> 65  -1.5150848179
#> 66  -0.1076788871
#> 67   0.0476258169
#> 68   0.1880160448
#> 69   4.0850294077
#> 70  -2.2914370123
#> 71   0.4167968986
#> 72   3.6958406482
#> 73  -1.4845537509
#> 74  -3.6214830475
#> 75  -0.4309627153
#> 76  -4.3332686184
#> 77   2.1894098588
#> 78   2.6042724675
#> 79   6.3080311830
#> 80   0.0312371596
#> 81   4.4995003021
#> 82  -1.3188410750
#> 83   1.8077162779
#> 84   1.0431359078
#> 85  -2.4192738556
#> 86   1.3649414859
#> 87  -2.6647154003
#> 88  -2.7888633687
#> 89   0.1291116578
#> 90   0.9924214232
#> 91  -2.9599281403
#> 92   2.5273915988
#> 93   0.2948935319
#> 94   1.9458473638
#> 95  -1.3244722192
#> 96  -0.1384464563
#> 97   0.6514191592
#> 98   1.8979066040
#> 99  -0.1440625187
#> 100 -1.0711330127
#> 101  0.0721478148
#> 102  2.7123886666
#> 103 -0.8583663959
#> 104 -1.5916040691
#> 105  2.1826217975
#> 106  1.5048624452
#> 107  0.2028414279
#> 108 -1.2074665550
#> 109 -2.2210511328
#> 110  3.9657713524
#> 111 -1.1048005860
#> 112 -0.6818818524
#> 113 -1.8645775672
#> 114 -2.0514609256
#> 115 -0.8998990442
#> 116 -2.7245359385
#> 117 -1.1491367534
#> 118  1.5961801233
#> 119 -2.1105392169
#> 120 -3.5137872371
#> 121  0.6146004905
#> 122  9.1200069237
#> 123  1.3229456689
#> 124  3.4825183943
#> 125 11.0324383079
#> 126  6.1674958791
#> 127  3.0710080886
#> 128  1.8763614324
#> 129 -0.5027636572
#> 130 -1.9514156082
#> 131  0.2839211763
#> 132  0.9426056966
#> 133 -3.6959191013
#> 134  0.7170411882
#> 135  3.4729621104
#> 136  2.6566347106
#> 137  3.0799231798
#> 138  0.4413736076
#> 139  0.2549332592
#> 140 -0.3074962284
#> 141  3.1331454561
#> 142 -0.4314172015
#> 143 -3.0166527858
#> 144 -0.2715888598
#> 145 -2.8779777003
#> 146  0.7130122757
#> 147 -1.5469113189
#> 148  1.8085779685
#> 149 -0.5396354043
#> 150 -0.2168693381
#> 151  0.9794232708
#> 152 -0.3076186945
#> 153 -2.0520069412
#> 154 -0.2122917143
#> 155  0.9915212434
#> 156 -0.9160114859
#> 157 -0.3694064786
#> 158  1.6809305156
#> 159  2.3149013221
#> 160 -1.6024136094
#> 161  1.4888862920
#> 162  0.3878546614
#> 163 -0.6253453281
#> 164 -0.3503377142
#> 165 -1.1342107814
#> 166 -0.1574447271
#> 167 -3.3578692459
#> 168 -2.1260149437
#> 169 -0.8853221243
#> 170 -0.3121733642
#> 171 -1.4451182903
#> 172 -2.0390391760
#> 173  0.0105304782
#> 174  0.2650878679
#> 175 -4.6394363439
#> 176 -0.5305617724
#> 177 -2.2659944002
#> 178 -2.3303431938
#> 179 -3.6694699550
#> 180 -2.6250208728
#> 181 -3.0829912432
#> 182  1.6179878515
#> 183 -2.2316761344
#> 184 -1.6714314434
#> 185 -4.9215386838
#> 186 -3.1200771552
#> 187  1.0727586773
#> 188 -3.7384397806
#> 189 -1.0599115222
#> 190  1.1570659215
#> 191  1.1704563519
#> 192  1.3652058157
#> 193  2.4556655672
#> 194 -2.0689241958
#> 195  1.0138767920
#> 196 -1.8290308618
#> 197  2.3928397170
#> 198  2.4496302937
#> 199 -0.9059431225
#> 200 -1.1627961331
#> 201 -3.3702729831
#> 202 -2.2825302634
#> 203 -0.2649422023
#> 204  0.1118624267
#> 205 -0.1227567562
#> 206 -0.8105997545
#> 207  1.9978917571
#> 208  3.0955805730
#> 209  0.6575422930
#> 210  3.6407620473
#> 211 -0.3895026353
#> 212 -1.8680652728
#> 213 -2.6713429431
#> 214  1.6262119175
#> 215 -0.1811675355
#> 216 -2.5826213023
#> 217  0.8106659529
#> 218 -1.2714092394
#> 219  1.5690429122
#> 220  0.3133571494
#> 221 -2.3637116265
#> 222 -2.4492093907
#> 223 -1.7833606884
#> 224 -2.8464907520
#> 225 -2.4753116230
#> 226 -2.4549010725
#> 227 -2.3511088921
#> 228 -2.4638808192
#> 229  2.2279822436
#> 230 -1.2754766419
#> 231  0.3663295275
#> 232 -2.0462672402
#> 233  4.2958991822
#> 234 -2.0212239558
#> 235 -0.8372559616
#> 236  2.2171228235
#> 237  2.8324923975
#> 238 -1.6489704339
#> 239  1.2979547011
#> 240  0.0981208862
#> 241  0.7599130849
#> 242  2.9258716077
#> 243  0.3968349971
#> 244  1.3148745046
#> 245 -1.2353069019
#> 246 -0.9091890420
#> 247  3.8257304704
#> 248  1.1227876032
#> 249  1.7070494982
#> 250 -0.3145568633
#> 
#> $PCs$pathway87
#>                V1
#> 1     0.106908261
#> 2    -1.328574127
#> 3     1.677265355
#> 4    -4.874630459
#> 5    -2.792893400
#> 6     1.244320176
#> 7    -2.231838575
#> 8    -0.013061945
#> 9     0.871568501
#> 10   -0.640310938
#> 11    2.133225289
#> 12    2.053508797
#> 13    0.960358760
#> 14    2.430447833
#> 15   -1.849834114
#> 16   -0.675838743
#> 17   -1.685882977
#> 18   -1.901918323
#> 19   -3.199352209
#> 20    5.224648028
#> 21    0.171359892
#> 22   -1.734418224
#> 23    2.113538536
#> 24    2.444833516
#> 25    0.766585981
#> 26    3.568096201
#> 27   -2.469731169
#> 28    1.302021801
#> 29    0.950154971
#> 30    1.662270005
#> 31   -2.217172720
#> 32   -0.442024816
#> 33   -0.168390212
#> 34   -4.230490162
#> 35   -2.633454811
#> 36   -1.038366838
#> 37   -6.406834317
#> 38    1.817380191
#> 39    0.292535677
#> 40    2.139145925
#> 41    1.674343599
#> 42    0.730875520
#> 43    1.403681921
#> 44    1.084697366
#> 45    0.546870552
#> 46    2.429468198
#> 47   -0.448080192
#> 48    0.332245665
#> 49    1.186410396
#> 50    0.560045932
#> 51   -1.810419615
#> 52   -1.779590779
#> 53    2.615041160
#> 54    1.556740926
#> 55    0.257113527
#> 56   -0.881781333
#> 57   -1.194985274
#> 58    2.104925394
#> 59   -0.972117940
#> 60   -2.230825582
#> 61    4.707547562
#> 62    1.633310025
#> 63   -0.218667275
#> 64   -0.506065016
#> 65   -1.519668499
#> 66   -1.014128155
#> 67   -1.056067785
#> 68    0.806428103
#> 69   -1.721503678
#> 70    0.321414320
#> 71    0.904870102
#> 72   -6.593132074
#> 73   -0.251670969
#> 74    1.859717112
#> 75    0.786169307
#> 76    1.615892603
#> 77   -1.484096525
#> 78   -2.828591801
#> 79   -7.347677087
#> 80    1.233197276
#> 81   -1.698398017
#> 82    2.586767813
#> 83   -2.216213100
#> 84   -1.941755937
#> 85    1.552275114
#> 86   -3.174333291
#> 87    2.371471635
#> 88    5.523030674
#> 89   -0.366177016
#> 90   -0.855893201
#> 91    2.762791944
#> 92   -3.615017781
#> 93    2.195703643
#> 94   -2.996283673
#> 95    0.048761628
#> 96    1.182320009
#> 97   -1.645991693
#> 98   -2.107407570
#> 99    0.824968170
#> 100   3.042597886
#> 101   0.142402583
#> 102  -2.771566553
#> 103  -0.253525828
#> 104   0.464463019
#> 105  -3.889387939
#> 106  -0.759738633
#> 107  -0.939551444
#> 108   0.876400483
#> 109   1.328017811
#> 110  -4.571145761
#> 111   0.780853049
#> 112  -0.813363888
#> 113   2.020108178
#> 114  -0.097019898
#> 115   0.638387156
#> 116   1.603185452
#> 117   0.080093279
#> 118  -1.387963908
#> 119   2.158479997
#> 120   1.141228395
#> 121   2.254557874
#> 122  -9.714694308
#> 123  -2.144157306
#> 124  -5.145837883
#> 125 -12.006685075
#> 126  -5.264275224
#> 127  -2.888163666
#> 128  -2.973130402
#> 129   2.645660507
#> 130   1.517092540
#> 131   3.088373635
#> 132  -0.205147042
#> 133   4.455269084
#> 134   1.579704944
#> 135  -5.109317169
#> 136  -0.965313923
#> 137   0.018510528
#> 138  -1.880966825
#> 139   0.473807349
#> 140   0.982757237
#> 141  -2.600371994
#> 142   1.018934931
#> 143   3.031229912
#> 144   2.008522431
#> 145   2.903734357
#> 146   0.390162442
#> 147   1.161382064
#> 148   0.282334902
#> 149   1.568361187
#> 150   0.719738909
#> 151  -2.232719574
#> 152   1.347467044
#> 153   3.048240377
#> 154   0.460701912
#> 155   1.332435944
#> 156  -0.525203883
#> 157  -1.256655924
#> 158  -5.029868902
#> 159  -2.608247278
#> 160  -0.275425271
#> 161  -1.270320401
#> 162  -1.104200681
#> 163   1.120692605
#> 164  -0.762387635
#> 165   0.499005986
#> 166  -1.259067994
#> 167   2.861238350
#> 168   3.197641061
#> 169   0.000691867
#> 170  -0.152771616
#> 171   0.017421686
#> 172   0.608636933
#> 173  -0.525778105
#> 174  -2.255641519
#> 175   1.099437233
#> 176   3.149536859
#> 177   1.932429919
#> 178   1.142631280
#> 179   3.793355155
#> 180   0.599361250
#> 181   4.941650794
#> 182  -3.736174737
#> 183   1.590579599
#> 184   1.693005641
#> 185   2.877909848
#> 186   1.196997625
#> 187  -1.528295096
#> 188   0.683760444
#> 189   0.324244890
#> 190  -1.691732747
#> 191  -0.586575080
#> 192  -2.399408359
#> 193  -3.507662903
#> 194   3.716734429
#> 195   1.105056708
#> 196   2.455609716
#> 197   0.525471966
#> 198  -0.468880878
#> 199   0.006291416
#> 200   3.912679535
#> 201   3.355917132
#> 202   0.789233291
#> 203   1.683762569
#> 204   1.421377336
#> 205  -0.274819162
#> 206   1.383463097
#> 207  -2.487879099
#> 208  -3.349380098
#> 209  -0.038078122
#> 210  -4.604856000
#> 211   4.566274125
#> 212   1.383171166
#> 213   2.696919854
#> 214  -2.412219079
#> 215  -0.763370604
#> 216   3.702848884
#> 217  -1.185674532
#> 218   1.704546546
#> 219  -1.469650065
#> 220  -2.140983840
#> 221   1.609228607
#> 222   0.233548011
#> 223   1.014759731
#> 224   3.365010278
#> 225   1.666803335
#> 226   1.439013796
#> 227   1.842608709
#> 228   2.574698139
#> 229  -2.275900455
#> 230   3.888854807
#> 231  -0.721952225
#> 232   3.383563199
#> 233  -4.134006923
#> 234   1.161685389
#> 235  -0.496575480
#> 236  -0.120556539
#> 237  -4.216273704
#> 238   4.098153491
#> 239   1.980908497
#> 240   1.533846042
#> 241  -1.501305346
#> 242   0.516898263
#> 243  -2.591698892
#> 244   0.379206553
#> 245   2.228119134
#> 246   1.031101086
#> 247  -2.810333585
#> 248  -0.996320469
#> 249  -3.580586779
#> 250   3.160262035
#> 
#> $PCs$pathway120
#>               V1
#> 1   -1.210794653
#> 2    0.610711837
#> 3    1.697217692
#> 4    0.757502144
#> 5    1.411593192
#> 6    0.038014763
#> 7   -2.017877533
#> 8    2.193770863
#> 9   -0.531801163
#> 10  -0.550746684
#> 11   4.982997600
#> 12   2.994984253
#> 13   3.748660949
#> 14   8.904035298
#> 15  -2.619010182
#> 16  -2.157938563
#> 17  -2.039716955
#> 18   3.499007433
#> 19  -5.397060960
#> 20   3.183502637
#> 21  -1.381389763
#> 22  -0.007174907
#> 23   0.342690239
#> 24  -3.973101500
#> 25  -0.580354680
#> 26  -2.640813140
#> 27  -0.724474835
#> 28   5.287618349
#> 29   9.107547081
#> 30  -0.905261067
#> 31   3.870598134
#> 32  -2.019446772
#> 33  -2.784459710
#> 34   1.632537782
#> 35  -1.851591032
#> 36   4.298216443
#> 37  -0.258951769
#> 38  -0.729843581
#> 39   0.425730216
#> 40   1.419681181
#> 41   2.641050469
#> 42   0.434317126
#> 43   1.782528937
#> 44   0.035262598
#> 45  -1.141155309
#> 46   1.192155120
#> 47  -0.631009614
#> 48   1.650022443
#> 49  -1.667107278
#> 50  -4.588450834
#> 51  -1.760424019
#> 52  -2.038017906
#> 53  -5.088975829
#> 54  -5.417450830
#> 55  -4.097700121
#> 56   4.013516886
#> 57  -2.282725696
#> 58   6.128793934
#> 59   4.244299167
#> 60  -5.365079223
#> 61  -2.780148442
#> 62  -0.427455980
#> 63   3.054665149
#> 64   2.354225514
#> 65   1.209895026
#> 66  -2.030863839
#> 67   0.878882273
#> 68  -1.219193693
#> 69   0.599970766
#> 70   2.633523625
#> 71  -2.470429436
#> 72  -2.742425563
#> 73   3.099522048
#> 74   0.346355945
#> 75  -1.992466273
#> 76   2.407463567
#> 77   5.847759504
#> 78   0.599049630
#> 79   0.753339711
#> 80  -0.680606917
#> 81  -0.281312240
#> 82  -1.351272586
#> 83  -3.798970850
#> 84   3.635367271
#> 85  -0.580840777
#> 86   6.044600681
#> 87  -1.061418063
#> 88   0.020212291
#> 89   4.401336343
#> 90   2.008463288
#> 91  -2.403001900
#> 92   0.611386044
#> 93   2.140756027
#> 94  -0.704019427
#> 95   0.940867864
#> 96  -0.275036644
#> 97   5.438016109
#> 98  -0.736528673
#> 99  -2.170453694
#> 100  1.537785494
#> 101  0.116928720
#> 102 -0.990784412
#> 103 -3.757999860
#> 104  7.763778250
#> 105 -0.811426483
#> 106  0.086256574
#> 107 -3.595524732
#> 108 -0.469570455
#> 109 -2.458662001
#> 110  2.320887065
#> 111 -2.621711345
#> 112 -2.306611645
#> 113  3.297934425
#> 114 -2.120397550
#> 115  3.514605532
#> 116 -1.977883140
#> 117  4.352657527
#> 118  0.736975095
#> 119 -0.419252956
#> 120 -0.669700415
#> 121  0.681714892
#> 122 -1.192932964
#> 123 -0.472693744
#> 124  4.176616767
#> 125 -1.948372587
#> 126 -1.701509806
#> 127  1.847701681
#> 128  4.512858880
#> 129  1.462559857
#> 130 -3.291635326
#> 131  0.716151144
#> 132  1.507428681
#> 133  4.793083717
#> 134 -0.745455045
#> 135  1.381282816
#> 136 -2.782728165
#> 137 -0.179603373
#> 138  0.352288049
#> 139  4.261532887
#> 140 -1.434111320
#> 141 -3.516342388
#> 142 -2.026434485
#> 143  3.897305577
#> 144 -3.004602232
#> 145 -2.229744989
#> 146 -0.112807827
#> 147  3.111671619
#> 148 -1.588650626
#> 149 -4.003222669
#> 150  4.229808005
#> 151 -3.753984004
#> 152 -0.876437713
#> 153  1.014183280
#> 154 -0.918603764
#> 155  0.194900025
#> 156 -0.292480968
#> 157 -0.487623702
#> 158  0.666922983
#> 159 -3.797488048
#> 160 -3.768789667
#> 161  2.598021847
#> 162 -0.337720512
#> 163  1.226593032
#> 164 -0.292902840
#> 165 -1.784147984
#> 166 -1.510578611
#> 167 -3.737933133
#> 168  1.956005391
#> 169 -3.643937382
#> 170 -0.481225023
#> 171 -2.457582451
#> 172 -0.787766231
#> 173  6.373044025
#> 174  0.499575570
#> 175 -0.653267444
#> 176  1.637001445
#> 177 -1.963503843
#> 178  0.646059701
#> 179 -0.872356231
#> 180  5.819749327
#> 181 -0.015304624
#> 182 -0.554243469
#> 183 -3.846099759
#> 184 -0.634203210
#> 185 -3.275421061
#> 186 -3.657864787
#> 187 10.015340443
#> 188 -1.910269926
#> 189  3.996068766
#> 190  6.562909284
#> 191  0.180458962
#> 192 -0.904466917
#> 193  0.163709187
#> 194 -2.874413753
#> 195 -2.088514435
#> 196 -4.379031229
#> 197 -0.140993181
#> 198  3.932547395
#> 199 -1.607985498
#> 200  3.101495508
#> 201  2.323745675
#> 202 -0.385884878
#> 203  4.035953530
#> 204  5.291699036
#> 205  0.481072071
#> 206 -1.119924345
#> 207  3.103873396
#> 208 -2.459658523
#> 209 -2.693371698
#> 210 -1.508881483
#> 211 -0.851023439
#> 212  0.360226985
#> 213  0.091326529
#> 214 -2.017194410
#> 215 -2.860414115
#> 216  0.619904304
#> 217  0.058314560
#> 218 -2.787706870
#> 219 -3.639314259
#> 220 -2.405303307
#> 221 -2.739859667
#> 222 -1.763356228
#> 223 -3.700288707
#> 224  0.397143842
#> 225 -1.319194820
#> 226 -2.095485122
#> 227 -3.255155378
#> 228 -3.933609156
#> 229  0.811697588
#> 230 -1.531342656
#> 231  1.772851428
#> 232  0.103585943
#> 233 -1.058326008
#> 234 -5.302880531
#> 235  1.083241588
#> 236  0.084357836
#> 237  2.539115331
#> 238  1.437206982
#> 239  0.797443051
#> 240 -1.167690259
#> 241  0.342513065
#> 242  1.998427499
#> 243 -2.657492676
#> 244 -0.802396774
#> 245 -4.024142274
#> 246  0.504303528
#> 247  4.366867791
#> 248 -0.692748689
#> 249 -3.342892571
#> 250 -6.384090541
#> 
#> $PCs$pathway176
#>               V1
#> 1    2.204634683
#> 2    1.587130824
#> 3    2.697762613
#> 4    0.033195977
#> 5    0.348580241
#> 6    2.402909053
#> 7   -1.111234215
#> 8   -0.326645613
#> 9    0.348869338
#> 10   0.307100539
#> 11   1.693854253
#> 12   2.983761764
#> 13   0.543680964
#> 14   1.967702325
#> 15  -0.441363458
#> 16  -0.867230004
#> 17  -3.493983425
#> 18  -2.137347688
#> 19  -4.449951863
#> 20   4.076364909
#> 21   1.675280455
#> 22  -2.448369455
#> 23   1.969957509
#> 24   4.407471879
#> 25   3.018642151
#> 26   4.407314569
#> 27   0.484544487
#> 28   1.268412271
#> 29   0.532280948
#> 30   2.612006472
#> 31  -3.998237547
#> 32  -0.008628012
#> 33   0.436724984
#> 34  -4.479318635
#> 35  -2.570942962
#> 36  -2.845808269
#> 37  -6.404689712
#> 38   0.770920674
#> 39  -0.892807566
#> 40   1.955537108
#> 41   0.118795052
#> 42  -0.647864518
#> 43   0.516554850
#> 44   1.551718804
#> 45   0.465146050
#> 46   1.484151671
#> 47   1.261776398
#> 48   1.159481231
#> 49   0.185058431
#> 50  -4.922695554
#> 51  -3.072288479
#> 52  -2.654365587
#> 53   1.853901484
#> 54  -0.053078974
#> 55  -0.757340373
#> 56  -1.002183954
#> 57  -0.732758210
#> 58   1.743126823
#> 59  -1.607194566
#> 60  -2.357013717
#> 61   4.544907413
#> 62   1.132181532
#> 63  -0.858505989
#> 64  -0.030324525
#> 65  -3.170885807
#> 66  -0.827346463
#> 67  -3.140622799
#> 68   2.338837400
#> 69  -1.043228817
#> 70   0.411821899
#> 71  -0.920543127
#> 72  -5.307723399
#> 73   0.137961685
#> 74   0.294911615
#> 75   0.631172150
#> 76   0.494705212
#> 77  -2.729718615
#> 78  -1.631446524
#> 79  -5.438144601
#> 80   3.100552038
#> 81   1.764885806
#> 82   2.470853479
#> 83  -1.895183918
#> 84  -1.641069951
#> 85   1.828157384
#> 86  -4.365892569
#> 87   0.672143805
#> 88   3.389707592
#> 89  -0.450997747
#> 90  -0.082708989
#> 91   2.012988896
#> 92  -2.751774091
#> 93   1.736370529
#> 94  -2.725920781
#> 95  -0.428211639
#> 96   0.778709743
#> 97  -2.041189316
#> 98  -0.899798184
#> 99   1.155247971
#> 100  3.235468849
#> 101 -1.033963609
#> 102 -1.754902068
#> 103  0.189198793
#> 104 -1.080968697
#> 105 -5.104024357
#> 106 -2.289970376
#> 107  0.616141517
#> 108  1.240412787
#> 109  1.954532423
#> 110 -5.226901262
#> 111  2.198634506
#> 112  1.007255035
#> 113  1.206827506
#> 114 -1.205903144
#> 115 -1.451206169
#> 116  0.612511901
#> 117  0.478489695
#> 118 -2.195898513
#> 119  1.709770491
#> 120 -0.665655750
#> 121  2.290825370
#> 122 -4.590333856
#> 123 -0.882421781
#> 124 -3.251811615
#> 125 -5.537653544
#> 126 -3.143411137
#> 127 -3.170325071
#> 128 -3.610846326
#> 129  1.858838073
#> 130  3.332266633
#> 131  3.710580767
#> 132  1.341959656
#> 133  3.719986269
#> 134  2.527247619
#> 135 -5.695855947
#> 136  2.100500751
#> 137  3.732617546
#> 138 -3.440862301
#> 139  2.295771884
#> 140  1.947931324
#> 141 -1.724950587
#> 142  3.133481644
#> 143  1.800523992
#> 144  4.031948475
#> 145  2.586675950
#> 146 -0.660398801
#> 147  0.769648960
#> 148 -1.246142504
#> 149  2.326332607
#> 150 -0.209633583
#> 151 -0.531403210
#> 152  2.040808521
#> 153  2.121837980
#> 154 -0.408295390
#> 155  2.051500541
#> 156 -0.108394169
#> 157 -1.644680057
#> 158 -4.971885624
#> 159 -1.764665666
#> 160 -0.989473626
#> 161 -1.129285446
#> 162 -1.844383919
#> 163  0.973901402
#> 164 -0.321478894
#> 165  0.221400906
#> 166 -0.897622515
#> 167  2.559216555
#> 168  2.864113538
#> 169  1.650973586
#> 170  0.555428646
#> 171  0.081608603
#> 172 -0.103611445
#> 173 -3.447968837
#> 174 -3.035978494
#> 175 -0.742436194
#> 176  1.712255071
#> 177  2.286611415
#> 178 -0.931712582
#> 179  1.943695624
#> 180 -1.447218540
#> 181 -0.088644851
#> 182 -5.310464576
#> 183  0.823751335
#> 184 -4.206869314
#> 185  2.359912005
#> 186  0.321709150
#> 187 -1.503381228
#> 188 -2.018048534
#> 189 -0.693623485
#> 190 -2.736194792
#> 191  0.430291059
#> 192 -2.023534669
#> 193 -5.063491546
#> 194  2.639437323
#> 195  0.583137363
#> 196  3.744814082
#> 197  3.968200088
#> 198  2.219265475
#> 199  1.006740722
#> 200  3.595555316
#> 201  2.517007510
#> 202  2.627948633
#> 203  2.983818136
#> 204  1.758802644
#> 205 -1.123880393
#> 206  3.317472135
#> 207 -3.011248058
#> 208 -4.071850303
#> 209 -0.973027403
#> 210 -4.379728267
#> 211  2.674001032
#> 212  1.314947587
#> 213  0.306242441
#> 214 -2.668175972
#> 215 -0.991991139
#> 216  1.669502618
#> 217 -0.515257507
#> 218  0.457125028
#> 219 -0.661240571
#> 220 -2.415718144
#> 221  0.803921369
#> 222  1.236003550
#> 223  1.175718200
#> 224  2.627094591
#> 225  1.877539384
#> 226  1.221380373
#> 227  2.068786931
#> 228  2.456193212
#> 229 -2.000412146
#> 230  3.933974522
#> 231 -0.584247756
#> 232  1.372036176
#> 233 -2.294579876
#> 234  1.143696567
#> 235  0.029103041
#> 236  2.205784994
#> 237 -4.116517117
#> 238  1.229267764
#> 239  4.038798724
#> 240  2.523725274
#> 241 -0.037078492
#> 242  3.520650916
#> 243 -2.231742946
#> 244  1.302604137
#> 245  2.735842144
#> 246 -0.014089211
#> 247 -3.828550673
#> 248 -1.376409204
#> 249 -3.680003343
#> 250  2.967112438
#> 
#> $PCs$pathway177
#>               V1
#> 1   -1.324803101
#> 2   -0.590394989
#> 3    1.776562814
#> 4   -0.069486146
#> 5    2.173258101
#> 6    0.198992910
#> 7   -1.852499174
#> 8    3.316390505
#> 9   -0.088119860
#> 10  -1.544822575
#> 11   4.889668601
#> 12   2.283173334
#> 13   4.214246106
#> 14   6.519106612
#> 15  -4.089560466
#> 16  -2.215837613
#> 17  -2.152743387
#> 18   2.955760772
#> 19  -4.576736807
#> 20   2.431839334
#> 21  -2.381413862
#> 22  -1.366941355
#> 23  -0.069041410
#> 24  -2.296057386
#> 25  -0.238968085
#> 26  -2.507196036
#> 27   0.240116703
#> 28   5.488232590
#> 29   6.169495959
#> 30  -0.299402189
#> 31   2.640502065
#> 32  -1.829317287
#> 33  -3.863490714
#> 34   1.150094271
#> 35  -1.185798332
#> 36   3.717368282
#> 37  -2.055092092
#> 38  -1.182233054
#> 39   1.265783563
#> 40   2.122088593
#> 41   1.884419115
#> 42   0.487715323
#> 43   2.585361372
#> 44   0.350145029
#> 45  -0.958789964
#> 46   1.509656944
#> 47  -0.165518797
#> 48   2.211944753
#> 49   0.332238557
#> 50  -0.779519566
#> 51  -1.717320800
#> 52  -2.161044935
#> 53  -4.026485326
#> 54  -4.726317469
#> 55  -3.302632290
#> 56   2.664008062
#> 57  -3.002713834
#> 58   4.372177302
#> 59   3.725657401
#> 60  -5.064853050
#> 61  -3.870329775
#> 62  -1.022659246
#> 63   0.473900979
#> 64   0.786001110
#> 65   0.923419252
#> 66  -2.877886762
#> 67   2.537632792
#> 68  -1.327562429
#> 69  -1.444511255
#> 70   1.703784574
#> 71  -4.632110673
#> 72  -1.833742378
#> 73   3.087780562
#> 74  -0.427663565
#> 75  -1.906991558
#> 76   2.034293540
#> 77   4.836531365
#> 78   0.303587154
#> 79   0.392690588
#> 80   0.008527016
#> 81   0.103349270
#> 82  -0.879769210
#> 83  -1.473702023
#> 84   3.838592517
#> 85  -0.697408334
#> 86   4.274398988
#> 87  -0.321207474
#> 88  -0.195241975
#> 89   5.136007750
#> 90   1.263038811
#> 91  -2.917517524
#> 92  -0.201189596
#> 93   0.828383720
#> 94  -1.589236097
#> 95   1.040359356
#> 96  -0.108181278
#> 97   4.256361179
#> 98  -1.071436632
#> 99  -2.726785904
#> 100  0.577726033
#> 101 -1.235211991
#> 102 -1.180786469
#> 103 -3.708018669
#> 104  4.701574917
#> 105 -1.912408348
#> 106 -0.495283606
#> 107 -2.291603048
#> 108 -1.556124979
#> 109 -3.613466187
#> 110  1.897424347
#> 111 -1.443798309
#> 112 -3.315043476
#> 113  1.373422734
#> 114 -1.437005563
#> 115  1.109744089
#> 116 -1.449960100
#> 117  3.275788048
#> 118  0.057507379
#> 119  0.647635691
#> 120 -0.499236922
#> 121  1.001302865
#> 122 -1.155737817
#> 123 -0.078169511
#> 124  2.917677666
#> 125 -2.983585917
#> 126 -1.023728642
#> 127  2.936731396
#> 128  2.751198438
#> 129  3.028615580
#> 130 -2.361210034
#> 131  0.629090058
#> 132  2.803264811
#> 133  4.690816064
#> 134 -0.465997036
#> 135  2.019655653
#> 136 -1.954570030
#> 137 -1.684375066
#> 138  1.052948842
#> 139  3.185058883
#> 140 -2.391996875
#> 141 -2.018296847
#> 142 -0.957009511
#> 143  2.888647812
#> 144 -1.429878212
#> 145 -1.598094806
#> 146 -1.765357521
#> 147  2.268321493
#> 148 -3.572941986
#> 149 -2.810424421
#> 150  3.496481084
#> 151 -3.929773600
#> 152 -0.749110158
#> 153  1.564730298
#> 154 -1.137090493
#> 155 -0.198085289
#> 156 -0.531711871
#> 157 -0.758910021
#> 158  1.407775053
#> 159 -2.929966182
#> 160 -3.539594355
#> 161  4.175675340
#> 162  0.717962329
#> 163 -0.215408521
#> 164  0.214030487
#> 165 -0.633864320
#> 166 -0.800155608
#> 167 -2.497793143
#> 168  1.624665638
#> 169 -3.965625483
#> 170 -0.856253226
#> 171 -1.013680118
#> 172 -2.009699611
#> 173  4.676222018
#> 174  0.664117598
#> 175  0.064627581
#> 176  2.350065688
#> 177 -1.182950483
#> 178  2.559997590
#> 179  0.503037400
#> 180  5.780473301
#> 181  2.434893018
#> 182  0.928767695
#> 183 -3.364717671
#> 184  5.669901579
#> 185 -1.979183716
#> 186 -2.801847015
#> 187  6.902259193
#> 188  0.027073221
#> 189  3.771671145
#> 190  5.064353731
#> 191 -1.678545250
#> 192  0.674485262
#> 193  0.410066579
#> 194 -2.685215746
#> 195 -2.412234838
#> 196 -1.249390224
#> 197  0.550971508
#> 198  2.467440568
#> 199 -0.384293582
#> 200  3.957304068
#> 201  3.434766293
#> 202 -0.789306754
#> 203  3.842067588
#> 204  6.563637398
#> 205  1.064150425
#> 206  0.017093473
#> 207  1.810011883
#> 208 -3.300261812
#> 209 -2.069370480
#> 210 -1.401472462
#> 211 -0.017293729
#> 212  0.954880653
#> 213  0.485558403
#> 214 -2.793936973
#> 215 -3.243505242
#> 216  1.469503993
#> 217 -1.476301043
#> 218 -2.573268728
#> 219 -2.261136190
#> 220 -2.708396014
#> 221 -2.849013359
#> 222 -1.138890571
#> 223 -4.899696499
#> 224  0.995686225
#> 225 -1.280173022
#> 226 -1.971289323
#> 227 -2.979676532
#> 228 -4.814798578
#> 229  0.972055805
#> 230 -0.755511664
#> 231  1.145466107
#> 232  0.344538725
#> 233 -2.181558808
#> 234 -4.606743380
#> 235  2.237726263
#> 236  0.413508944
#> 237  1.676065148
#> 238  0.738194139
#> 239 -0.051935897
#> 240 -0.056564082
#> 241  0.758021473
#> 242  0.797443873
#> 243 -1.651636479
#> 244  0.551952842
#> 245 -2.438887829
#> 246  0.365746568
#> 247  2.733837964
#> 248  0.430409400
#> 249 -2.950933396
#> 250 -5.413903941
#> 
#> $PCs$pathway187
#>               V1
#> 1    1.199346948
#> 2   -0.545227001
#> 3    0.392805427
#> 4   -1.344171695
#> 5   -4.202408333
#> 6   -3.938622879
#> 7   -0.903803408
#> 8   -3.401273438
#> 9    0.927509485
#> 10   0.796232782
#> 11   0.244979707
#> 12   0.755383534
#> 13  -0.895334323
#> 14   0.353334028
#> 15  -1.791361575
#> 16   1.882996901
#> 17   2.076092241
#> 18  -1.202458071
#> 19  -1.034844603
#> 20  -1.816236141
#> 21  -0.799588963
#> 22   0.705516574
#> 23  -1.959570228
#> 24   0.880546960
#> 25  -3.000217411
#> 26   0.981163330
#> 27   0.981252608
#> 28  -2.743590606
#> 29   0.258147760
#> 30   0.931424858
#> 31  -0.260498127
#> 32   1.912481466
#> 33   1.749677259
#> 34  -2.143144112
#> 35   0.300475094
#> 36  -0.950407960
#> 37  -1.445759160
#> 38   1.641962218
#> 39   0.012384236
#> 40   1.099002184
#> 41   0.316435901
#> 42  -2.312922279
#> 43   0.242183460
#> 44   0.762253628
#> 45   1.511941675
#> 46  -0.393640802
#> 47   0.230049555
#> 48  -0.075880789
#> 49  -0.012528399
#> 50   1.007974686
#> 51  -0.886974474
#> 52  -0.729650158
#> 53   3.688932285
#> 54   2.321441951
#> 55   1.946041712
#> 56  -1.636782799
#> 57   2.087535000
#> 58  -1.829795379
#> 59  -0.559827374
#> 60   0.686347000
#> 61   0.964313697
#> 62   2.027482803
#> 63  -0.213192246
#> 64   0.548618612
#> 65  -0.960951280
#> 66   2.590259679
#> 67  -1.780677297
#> 68   1.756392465
#> 69  -1.641184904
#> 70  -1.657742418
#> 71  -0.009431618
#> 72  -4.054109621
#> 73   0.189874590
#> 74   0.227030257
#> 75   1.303825788
#> 76   1.558272425
#> 77  -1.765029434
#> 78   0.453701334
#> 79  -2.831893418
#> 80   0.521641347
#> 81  -1.488456258
#> 82   1.770866268
#> 83   1.088508215
#> 84  -0.414089873
#> 85   1.413135207
#> 86  -2.384879706
#> 87  -0.720098774
#> 88   0.279128920
#> 89  -1.577027459
#> 90  -0.388721741
#> 91   2.265314379
#> 92  -0.245512045
#> 93   0.820991400
#> 94   1.382851181
#> 95   0.197523004
#> 96   0.291729556
#> 97  -0.426782193
#> 98  -0.318290846
#> 99   1.453486041
#> 100  0.937979090
#> 101 -1.600934738
#> 102  1.486340223
#> 103  1.869593036
#> 104 -0.240159106
#> 105 -2.607839545
#> 106 -0.600681553
#> 107 -0.455756856
#> 108  0.283567548
#> 109  2.296167150
#> 110 -2.251268877
#> 111  0.588086995
#> 112  1.225679377
#> 113 -0.148917890
#> 114 -0.953514791
#> 115  0.187152048
#> 116  0.064454887
#> 117 -0.404040459
#> 118  0.739692798
#> 119  2.692946897
#> 120  1.719549811
#> 121 -1.009061376
#> 122 -1.335234395
#> 123  0.349685781
#> 124 -1.431382915
#> 125 -1.453132326
#> 126  0.034354927
#> 127 -0.837931697
#> 128 -0.050134848
#> 129  0.555580982
#> 130  1.826496353
#> 131 -0.199218801
#> 132  1.627791665
#> 133 -1.104994793
#> 134  0.899371244
#> 135 -1.654919921
#> 136  2.018835811
#> 137  0.528168120
#> 138 -0.599971530
#> 139  0.556883389
#> 140  1.831090524
#> 141 -0.366525317
#> 142 -0.013109334
#> 143 -0.532386535
#> 144  2.215812444
#> 145  1.646073207
#> 146  1.716149950
#> 147 -1.307842732
#> 148 -0.138223019
#> 149 -0.174569262
#> 150  0.267315306
#> 151  1.712881670
#> 152  0.079272825
#> 153 -1.468927671
#> 154 -0.772000026
#> 155 -0.370098503
#> 156  0.091894513
#> 157 -0.618877999
#> 158 -4.677584895
#> 159 -1.580957480
#> 160  1.359494460
#> 161 -1.127182720
#> 162 -2.329778307
#> 163  1.293429794
#> 164 -0.725437057
#> 165 -1.559996896
#> 166 -0.541059369
#> 167  0.984197640
#> 168  0.767174586
#> 169  1.932903526
#> 170  1.150693302
#> 171 -0.081817604
#> 172 -0.796538449
#> 173 -0.655999691
#> 174 -0.785637256
#> 175  0.459802762
#> 176 -0.323537825
#> 177 -0.579861288
#> 178 -1.733518909
#> 179  2.555460723
#> 180 -0.908321704
#> 181 -0.486390581
#> 182 -3.150062529
#> 183  1.569812778
#> 184 -5.140891699
#> 185  1.489132599
#> 186  0.391126161
#> 187 -1.661491619
#> 188 -0.749344964
#> 189 -0.096989762
#> 190 -0.040489562
#> 191  2.700995202
#> 192 -1.162650945
#> 193 -2.468825417
#> 194  1.304599420
#> 195  0.861355193
#> 196  1.610726248
#> 197 -1.949092767
#> 198  1.135704737
#> 199 -0.128293294
#> 200  0.521714925
#> 201 -0.275323799
#> 202  0.188209070
#> 203 -0.577264271
#> 204 -2.200994759
#> 205  0.070964771
#> 206  1.503842826
#> 207 -2.193867757
#> 208 -0.372524164
#> 209  0.116876414
#> 210 -1.606865057
#> 211  2.875102770
#> 212  0.108395875
#> 213 -0.875402915
#> 214  3.188006189
#> 215  1.832695606
#> 216 -0.858370533
#> 217  1.008416315
#> 218 -2.156600941
#> 219  0.595963601
#> 220 -0.338547861
#> 221  1.827749072
#> 222  0.342666052
#> 223  0.674711273
#> 224 -0.565469363
#> 225 -0.284542475
#> 226  3.086480093
#> 227  1.289203160
#> 228  1.144298463
#> 229  0.985999932
#> 230  0.749500234
#> 231 -0.159135510
#> 232 -1.058414101
#> 233 -3.029220836
#> 234  1.841870608
#> 235  1.148854520
#> 236  0.345923673
#> 237 -0.619026369
#> 238  0.365497076
#> 239  0.959396001
#> 240  1.565408694
#> 241  1.275612641
#> 242 -0.255292677
#> 243 -0.624232091
#> 244  0.711745696
#> 245  2.227666578
#> 246  0.992492355
#> 247 -2.097378005
#> 248  1.397963794
#> 249 -0.286670083
#> 250 -0.274361011
#> 
#> $PCs$pathway266
#>               V1
#> 1   -0.934921963
#> 2   -3.147551945
#> 3    0.261042678
#> 4   -2.839793913
#> 5   -2.098295919
#> 6   -0.120913668
#> 7    0.386271880
#> 8   -2.181703202
#> 9   -0.291354846
#> 10   0.876765109
#> 11   4.481976495
#> 12   0.758447987
#> 13  -1.125839748
#> 14   3.729491958
#> 15  -0.145516173
#> 16   0.409524480
#> 17   1.507623356
#> 18  -1.154454896
#> 19  -2.055690052
#> 20   3.045883935
#> 21  -1.060882444
#> 22   1.990775346
#> 23  -0.401349016
#> 24   0.125412103
#> 25  -0.162668474
#> 26  -0.687411325
#> 27  -0.410133844
#> 28  -1.049775965
#> 29   4.714690206
#> 30   0.078036929
#> 31   2.267327318
#> 32   0.215976763
#> 33   0.968488039
#> 34   3.032917471
#> 35  -1.035171205
#> 36   2.860294497
#> 37  -0.481098914
#> 38   0.536953228
#> 39   1.010387144
#> 40   0.897629569
#> 41   0.085544612
#> 42  -1.221235685
#> 43   1.166338106
#> 44  -0.627257154
#> 45  -1.484338914
#> 46  -1.861201044
#> 47   0.893780453
#> 48  -2.577064310
#> 49  -0.573186259
#> 50  -1.726010009
#> 51  -1.896547819
#> 52  -0.893175700
#> 53  -1.423993251
#> 54   1.107074492
#> 55   0.227575805
#> 56   0.026004568
#> 57  -1.679347274
#> 58   0.133210383
#> 59  -0.099879345
#> 60  -1.252698805
#> 61  -2.571679197
#> 62   1.884130423
#> 63   1.275176576
#> 64   0.874207466
#> 65   0.233218208
#> 66   0.908918359
#> 67  -1.994855319
#> 68   0.879343483
#> 69  -0.559442563
#> 70   0.724436765
#> 71   1.251960345
#> 72  -3.696097917
#> 73   1.950132756
#> 74   2.136723101
#> 75  -0.605889865
#> 76   1.974134155
#> 77   0.352753243
#> 78  -0.578113113
#> 79  -1.354282257
#> 80   0.965417020
#> 81  -2.599658646
#> 82  -0.534266900
#> 83   0.767488437
#> 84   1.423864325
#> 85  -0.014289708
#> 86   4.435663135
#> 87  -3.546527255
#> 88   0.515822363
#> 89  -0.209235031
#> 90   1.134624900
#> 91  -0.077834219
#> 92   0.659890816
#> 93  -0.405436510
#> 94   0.593356979
#> 95  -1.062084572
#> 96  -1.239692446
#> 97   4.196982327
#> 98  -1.979760394
#> 99  -1.395745354
#> 100  0.965018601
#> 101  1.631261063
#> 102 -1.914882450
#> 103 -0.540616556
#> 104  2.604895791
#> 105 -1.770836706
#> 106 -1.432343325
#> 107 -0.496999577
#> 108  0.101103965
#> 109 -0.326114635
#> 110  0.991665675
#> 111 -0.067286291
#> 112  0.479013423
#> 113  0.517705487
#> 114  0.302558947
#> 115  4.242989856
#> 116 -1.673909685
#> 117  2.562612746
#> 118  0.394747049
#> 119  2.043978159
#> 120  4.494520791
#> 121 -0.038986891
#> 122 -1.437298475
#> 123 -1.634736417
#> 124  0.172136160
#> 125 -0.363698755
#> 126 -2.252648602
#> 127  1.282571572
#> 128  2.854923146
#> 129 -0.384549893
#> 130  0.039920308
#> 131 -1.797685196
#> 132  3.510916672
#> 133  0.496907835
#> 134  0.236816935
#> 135 -2.124202141
#> 136 -1.756648627
#> 137  0.865232751
#> 138  0.545545411
#> 139  1.715471496
#> 140  0.458414236
#> 141 -0.997121441
#> 142 -0.945843293
#> 143  3.489325159
#> 144 -0.181268464
#> 145 -2.183050712
#> 146  0.902564172
#> 147  0.680621218
#> 148 -1.220946489
#> 149  0.052058969
#> 150  1.634054012
#> 151 -0.205261826
#> 152 -0.993012453
#> 153 -0.751749041
#> 154 -0.399162455
#> 155 -0.890061997
#> 156 -0.270933393
#> 157  2.068418335
#> 158  1.196618058
#> 159  0.112230191
#> 160  0.316015593
#> 161 -3.405112820
#> 162 -0.053802416
#> 163 -0.584783261
#> 164 -1.356516048
#> 165  0.188196866
#> 166 -0.739315169
#> 167  0.093544000
#> 168  1.973984922
#> 169 -0.494253355
#> 170 -1.664187961
#> 171  2.525306561
#> 172 -0.345038652
#> 173  2.048509242
#> 174 -1.186438984
#> 175  0.639634901
#> 176 -1.514850192
#> 177 -1.528191879
#> 178 -2.363814574
#> 179  0.001158122
#> 180  3.770457903
#> 181 -4.085760743
#> 182 -1.824416998
#> 183  0.350643006
#> 184 -1.901586193
#> 185  0.224054407
#> 186 -1.669851038
#> 187  2.479171161
#> 188  2.180400543
#> 189  2.341253250
#> 190  3.345794343
#> 191 -1.502626427
#> 192 -1.245982349
#> 193 -1.582614879
#> 194  0.211327404
#> 195  0.630600728
#> 196  0.573064051
#> 197  0.984396414
#> 198  1.318742310
#> 199  1.193969047
#> 200 -2.481058280
#> 201  0.663982332
#> 202 -1.830534732
#> 203  1.472853449
#> 204 -1.552704250
#> 205 -1.391472379
#> 206 -0.764663034
#> 207  0.400191718
#> 208 -0.118544118
#> 209 -2.043855400
#> 210 -2.936885789
#> 211 -1.547451802
#> 212  0.326127838
#> 213  0.066150744
#> 214  2.478015140
#> 215  0.364048091
#> 216  1.306846654
#> 217 -0.034224483
#> 218 -1.889116551
#> 219  1.220557943
#> 220 -0.259796148
#> 221  0.010134887
#> 222 -2.099768335
#> 223 -0.880954418
#> 224  1.715594223
#> 225 -1.471416526
#> 226  0.609472920
#> 227  0.077585102
#> 228 -0.087832382
#> 229 -0.978188898
#> 230  0.663067452
#> 231 -0.336820661
#> 232 -2.225987201
#> 233 -2.506646824
#> 234 -0.210692535
#> 235  0.053799080
#> 236 -1.581956129
#> 237 -0.559305568
#> 238 -0.561699327
#> 239 -0.553391650
#> 240 -1.253050061
#> 241  0.996488795
#> 242 -1.060848036
#> 243 -0.380856269
#> 244 -0.879653888
#> 245  1.998093355
#> 246  0.410817622
#> 247  0.082875549
#> 248  1.281733003
#> 249  0.451073187
#> 250  1.085487603
#> 
#> $PCs$pathway390
#>               V1
#> 1   -1.397389606
#> 2   -0.101854562
#> 3   -2.390415152
#> 4    3.370981040
#> 5   -0.352270562
#> 6   -0.770105891
#> 7    0.400706609
#> 8    0.682743990
#> 9    0.979189857
#> 10  -0.825616338
#> 11  -3.663191847
#> 12  -1.792893843
#> 13  -0.367397752
#> 14  -4.997681094
#> 15   2.439812034
#> 16   0.565335907
#> 17   1.227306865
#> 18   3.317599729
#> 19   5.440247089
#> 20  -5.494654058
#> 21  -1.592493901
#> 22  -1.533939885
#> 23   0.101984948
#> 24  -4.159802691
#> 25  -0.491651854
#> 26  -2.086513364
#> 27  -0.782334938
#> 28  -0.679286140
#> 29  -2.903840204
#> 30  -1.430258656
#> 31   1.340870843
#> 32  -1.580508600
#> 33  -1.457268085
#> 34   0.265286551
#> 35   1.787846425
#> 36   0.675448101
#> 37   4.420692173
#> 38   0.714427993
#> 39  -0.416767176
#> 40  -2.023185857
#> 41  -1.631961871
#> 42   0.527849350
#> 43  -1.625091578
#> 44  -0.921376747
#> 45   1.354810808
#> 46  -0.176134636
#> 47   0.235298599
#> 48   0.192150555
#> 49   1.319682951
#> 50   3.321034029
#> 51   3.250756505
#> 52   1.031695935
#> 53  -0.791357762
#> 54   0.260522024
#> 55   1.485624413
#> 56   1.068500564
#> 57   0.374881075
#> 58  -1.988689292
#> 59   1.408593516
#> 60   1.945375380
#> 61  -2.568323817
#> 62  -2.861758182
#> 63  -0.284259987
#> 64  -0.523108764
#> 65   2.552171159
#> 66  -0.356529594
#> 67   3.483786298
#> 68  -1.855364776
#> 69   0.296598979
#> 70  -0.529852176
#> 71  -0.997155550
#> 72   7.399924776
#> 73  -1.910403056
#> 74  -0.750969767
#> 75  -0.082116098
#> 76  -1.513227954
#> 77   1.400780191
#> 78   0.382648202
#> 79   3.512365771
#> 80  -2.179770896
#> 81   1.167171666
#> 82  -2.181597392
#> 83   1.920399900
#> 84   0.296979688
#> 85  -0.295310266
#> 86   1.518424822
#> 87   1.102988223
#> 88  -1.008404719
#> 89   1.245446840
#> 90  -0.034943172
#> 91  -2.162697274
#> 92   1.073394206
#> 93  -1.203473271
#> 94   0.664371214
#> 95   0.344961163
#> 96  -2.129829476
#> 97  -0.904237887
#> 98  -0.551948610
#> 99  -0.761991854
#> 100 -1.851457955
#> 101 -0.809669009
#> 102  1.384121385
#> 103 -0.507620570
#> 104 -1.865276483
#> 105  4.533344494
#> 106  1.222590275
#> 107  0.501089715
#> 108  0.449382036
#> 109  0.301420281
#> 110  4.036216973
#> 111 -0.056190899
#> 112 -0.019599597
#> 113 -1.042206218
#> 114  1.851440678
#> 115 -1.931269075
#> 116  1.022328146
#> 117 -1.421883312
#> 118  0.433587333
#> 119 -1.714104826
#> 120 -2.006190821
#> 121 -2.808370540
#> 122  0.847741007
#> 123  0.413536524
#> 124  1.462647769
#> 125  3.620304706
#> 126  1.834914611
#> 127  1.074985775
#> 128  0.034088261
#> 129 -0.538697674
#> 130 -3.149277091
#> 131 -1.342101984
#> 132 -4.220085913
#> 133 -1.780940272
#> 134 -0.071277746
#> 135  4.793277522
#> 136 -0.469493867
#> 137 -1.255982231
#> 138  2.529393507
#> 139 -3.164401956
#> 140 -1.847473055
#> 141  2.050957011
#> 142 -0.757139709
#> 143 -3.394051134
#> 144 -1.590094944
#> 145 -2.072597126
#> 146 -1.703171739
#> 147  0.568709189
#> 148  1.399286944
#> 149 -0.612028542
#> 150 -1.478243191
#> 151  1.452771085
#> 152 -0.891921253
#> 153 -0.997685738
#> 154  1.639350873
#> 155 -1.307508061
#> 156 -0.062388662
#> 157 -1.050715692
#> 158  3.119788540
#> 159  1.465049470
#> 160  0.032643619
#> 161  3.703504483
#> 162  0.789037144
#> 163  0.335280277
#> 164  2.520720991
#> 165  0.810470378
#> 166  1.264688938
#> 167  0.598178432
#> 168 -1.421139585
#> 169 -0.243801308
#> 170  0.481373026
#> 171 -0.515535934
#> 172 -0.381712153
#> 173  0.864727444
#> 174  3.648983547
#> 175  1.209768656
#> 176  0.027691528
#> 177 -1.563894432
#> 178  1.572856263
#> 179 -2.155430005
#> 180 -1.326991363
#> 181  2.212154505
#> 182  4.752103150
#> 183  1.406713154
#> 184  3.826615144
#> 185 -1.057203999
#> 186  1.272161263
#> 187 -2.267284198
#> 188 -0.662726717
#> 189 -1.196612599
#> 190 -1.155012432
#> 191 -1.002292588
#> 192  1.020025949
#> 193  4.120074308
#> 194 -0.852079294
#> 195  0.004215399
#> 196 -1.723875314
#> 197 -2.849145821
#> 198 -3.913167810
#> 199 -0.457955628
#> 200 -0.543558140
#> 201 -2.626161895
#> 202 -2.423419069
#> 203 -3.851289608
#> 204 -0.999967015
#> 205  0.562319242
#> 206 -1.280828736
#> 207  1.658518983
#> 208  3.808780971
#> 209  0.364953230
#> 210  4.744683493
#> 211  0.091193848
#> 212 -0.715428935
#> 213  0.794061420
#> 214  0.549447738
#> 215 -0.371683956
#> 216 -1.483232971
#> 217 -0.622080942
#> 218  1.035085444
#> 219  1.551383599
#> 220  2.576363037
#> 221 -0.816391932
#> 222  0.856340006
#> 223 -0.075179847
#> 224 -1.085706392
#> 225 -0.300142520
#> 226 -1.533936530
#> 227 -0.301153876
#> 228 -1.982016515
#> 229  2.840411252
#> 230 -3.222470882
#> 231  1.987447155
#> 232 -0.207874141
#> 233  3.127333143
#> 234 -0.225981360
#> 235 -0.268506038
#> 236 -1.012832212
#> 237  1.950903560
#> 238 -1.642361309
#> 239 -3.365247647
#> 240 -1.806762758
#> 241 -0.529727938
#> 242 -1.670013296
#> 243  3.540192653
#> 244 -1.598903766
#> 245 -0.875192769
#> 246 -0.080835544
#> 247  2.095366904
#> 248 -0.389248794
#> 249  2.301317521
#> 250 -0.303759985
#> 
#> $PCs$pathway413
#>              V1
#> 1    1.36959354
#> 2    2.50947169
#> 3    0.45002339
#> 4   -0.16377047
#> 5    0.06197076
#> 6    1.04785573
#> 7   -0.20194592
#> 8   -0.67808900
#> 9    0.46386255
#> 10   2.28333251
#> 11   0.71584287
#> 12   2.35568231
#> 13   0.78911966
#> 14   1.09293802
#> 15  -1.02906085
#> 16  -1.97541794
#> 17  -0.08231869
#> 18  -1.96556608
#> 19  -4.59889082
#> 20   1.36844524
#> 21   1.75607137
#> 22  -0.56553235
#> 23   0.15342808
#> 24   0.32465232
#> 25   0.22403057
#> 26   2.43121614
#> 27   0.50899314
#> 28  -0.24494293
#> 29   0.04554151
#> 30   2.36989875
#> 31  -1.68654422
#> 32   0.94110670
#> 33   1.28366799
#> 34  -1.21737026
#> 35  -1.00153471
#> 36  -1.46737093
#> 37  -4.65577488
#> 38   0.37531500
#> 39   0.87330967
#> 40   0.71549096
#> 41   0.88385175
#> 42   1.66224325
#> 43   1.18842211
#> 44   2.02370255
#> 45   0.35904410
#> 46   0.60904002
#> 47   0.59233552
#> 48   1.27601215
#> 49   0.41502341
#> 50  -3.18461096
#> 51  -3.03972450
#> 52  -2.17609505
#> 53  -1.42511757
#> 54   0.81973367
#> 55  -2.50208799
#> 56  -0.55714144
#> 57   0.73723792
#> 58   1.18108886
#> 59  -0.97774495
#> 60  -1.53812803
#> 61   2.97864280
#> 62   0.52573234
#> 63  -0.41314630
#> 64   1.15593261
#> 65  -3.89183739
#> 66  -0.04149395
#> 67  -2.82303161
#> 68   1.39125692
#> 69   0.52825395
#> 70  -0.47255737
#> 71  -0.04034459
#> 72  -5.09195197
#> 73   1.44925518
#> 74   0.10249059
#> 75   1.50188586
#> 76   1.57146321
#> 77  -0.63135346
#> 78  -0.14257369
#> 79  -2.34042193
#> 80   1.56442235
#> 81   1.05535918
#> 82   1.87516659
#> 83  -1.56663385
#> 84  -1.62184466
#> 85   0.14462867
#> 86  -2.92601928
#> 87   0.14128695
#> 88   1.48659964
#> 89  -0.65195218
#> 90  -0.06118812
#> 91   1.96243063
#> 92  -1.82999734
#> 93   0.86979093
#> 94  -1.38801984
#> 95  -0.71021031
#> 96   1.45936469
#> 97  -0.58564735
#> 98  -0.08415761
#> 99   0.40199185
#> 100  1.13475602
#> 101 -0.82250784
#> 102 -0.91344186
#> 103  0.46195563
#> 104 -1.14229788
#> 105 -3.03155413
#> 106 -1.45713526
#> 107 -0.56361445
#> 108  0.59819052
#> 109  1.43493639
#> 110 -2.95528419
#> 111  1.22071716
#> 112  1.71652289
#> 113  1.68777786
#> 114 -0.22877525
#> 115 -0.41836048
#> 116  0.03696517
#> 117  0.10705298
#> 118 -0.45059537
#> 119  2.17377976
#> 120  1.64612173
#> 121  2.47080852
#> 122 -1.23635251
#> 123  0.21093030
#> 124 -2.26344688
#> 125 -2.35693013
#> 126 -0.90046101
#> 127 -1.77769651
#> 128 -0.26925987
#> 129 -0.05532968
#> 130  1.87913886
#> 131  1.25771744
#> 132  1.37319755
#> 133  1.85882323
#> 134  1.83951094
#> 135 -3.27261584
#> 136  0.47678239
#> 137  1.44632591
#> 138 -1.91949629
#> 139  2.07872521
#> 140  1.24775709
#> 141 -0.41475441
#> 142  1.33219387
#> 143  1.66908234
#> 144  0.44579903
#> 145  0.27848600
#> 146  0.40542467
#> 147 -0.96433035
#> 148  1.45365419
#> 149  0.71140240
#> 150  1.27893138
#> 151 -0.78902212
#> 152  1.86455207
#> 153  0.92950482
#> 154 -1.43940200
#> 155  2.27997594
#> 156 -0.18510897
#> 157 -0.58612625
#> 158 -3.85149777
#> 159 -0.12485338
#> 160 -0.43676724
#> 161 -1.68993605
#> 162 -1.24159295
#> 163  0.24642710
#> 164 -0.85539894
#> 165 -0.77086755
#> 166 -0.78394883
#> 167 -0.42178978
#> 168  2.92966273
#> 169  0.90378551
#> 170 -0.14592885
#> 171  0.13876026
#> 172  1.07384161
#> 173 -1.98910631
#> 174 -2.94367797
#> 175 -0.40925453
#> 176  1.57391347
#> 177  2.63468508
#> 178  0.42067536
#> 179  1.54465041
#> 180 -0.69106116
#> 181 -3.01457888
#> 182 -3.83307235
#> 183  0.25965012
#> 184 -4.30756860
#> 185  1.27412655
#> 186  0.65580075
#> 187 -0.91171440
#> 188  0.05855548
#> 189  0.07596351
#> 190 -0.50172025
#> 191  0.53303691
#> 192 -0.97873882
#> 193 -3.19209083
#> 194  0.72281881
#> 195 -0.16427815
#> 196  2.31310248
#> 197  1.75101992
#> 198  1.19210749
#> 199 -0.50206453
#> 200  1.42916313
#> 201  2.14832699
#> 202  0.86582736
#> 203  2.47106713
#> 204  0.45450382
#> 205 -1.15066771
#> 206  1.19490282
#> 207 -2.57596550
#> 208 -1.94681870
#> 209  0.30245708
#> 210 -2.66599036
#> 211  0.31710365
#> 212  0.01979172
#> 213 -0.87070549
#> 214 -1.58494804
#> 215 -0.25941198
#> 216 -0.04947992
#> 217  0.09338945
#> 218 -0.65049250
#> 219 -0.94515523
#> 220 -2.86017303
#> 221  0.83346218
#> 222  1.23656168
#> 223  1.46833474
#> 224  0.23322838
#> 225  0.95606301
#> 226  0.85286194
#> 227  0.75895996
#> 228  2.23112885
#> 229 -1.36338056
#> 230  2.51776042
#> 231  0.07014218
#> 232  1.01435174
#> 233 -0.11396673
#> 234  1.83318524
#> 235 -2.08764249
#> 236  2.37942518
#> 237 -1.43397184
#> 238  0.25676449
#> 239  1.33287461
#> 240  2.03604410
#> 241 -0.50226408
#> 242  3.51918353
#> 243 -2.89486567
#> 244  0.26619887
#> 245  0.67134471
#> 246 -0.03184464
#> 247 -2.14724174
#> 248 -0.63962900
#> 249 -1.77092498
#> 250  1.47106770
#> 
#> $PCs$pathway491
#>               V1
#> 1   -0.906154359
#> 2   -0.456595596
#> 3   -2.001530596
#> 4    3.195259723
#> 5   -1.322445334
#> 6    1.497953949
#> 7    2.120284830
#> 8   -1.036638009
#> 9   -0.334769683
#> 10   1.372241948
#> 11   0.818515592
#> 12  -1.475014811
#> 13  -3.284344367
#> 14  -2.149417516
#> 15   2.247266154
#> 16   0.342912448
#> 17   0.942173175
#> 18   2.053897950
#> 19   3.737221643
#> 20  -1.421301000
#> 21   1.134824225
#> 22   2.256774411
#> 23  -0.350377947
#> 24  -0.590784833
#> 25   0.017020320
#> 26  -1.652945039
#> 27   0.427927446
#> 28  -5.029979838
#> 29  -0.157737735
#> 30   0.019665051
#> 31   2.680087948
#> 32  -0.462988293
#> 33   1.228411366
#> 34   3.703476557
#> 35   1.051678094
#> 36  -0.017159801
#> 37   5.358083343
#> 38   0.155614503
#> 39  -0.530426752
#> 40  -2.456479346
#> 41  -1.474605098
#> 42  -0.132832213
#> 43  -0.319946702
#> 44  -0.618603385
#> 45  -0.614084570
#> 46  -1.396637563
#> 47   0.989304555
#> 48  -1.349315585
#> 49  -2.153503794
#> 50  -2.824216834
#> 51   1.399831285
#> 52   0.622624575
#> 53  -2.487597852
#> 54  -1.177405862
#> 55   0.669541011
#> 56   1.250766614
#> 57   0.644626843
#> 58  -2.155101959
#> 59  -1.575448277
#> 60   1.284001609
#> 61  -2.403322413
#> 62  -1.594294034
#> 63   0.619549513
#> 64   1.135706692
#> 65   1.228137826
#> 66  -0.307017624
#> 67  -0.693627779
#> 68   0.801396448
#> 69   1.753580158
#> 70   0.049992170
#> 71   1.058956482
#> 72   6.617112575
#> 73   0.539608402
#> 74   0.558130880
#> 75   1.029038642
#> 76   0.739022023
#> 77   0.657023618
#> 78   2.196194323
#> 79   3.702281276
#> 80  -0.952676721
#> 81  -0.041898735
#> 82  -1.424674584
#> 83   1.278581133
#> 84   1.368919029
#> 85  -0.628138803
#> 86   2.598519466
#> 87  -3.593935276
#> 88  -1.777236944
#> 89  -2.654823757
#> 90   0.380767850
#> 91  -1.446635010
#> 92   1.620786749
#> 93  -1.127865285
#> 94   3.154667767
#> 95  -1.229044021
#> 96  -2.006046945
#> 97   0.940426778
#> 98  -0.295758568
#> 99  -1.265265316
#> 100 -1.305260385
#> 101 -0.348730543
#> 102  2.726395447
#> 103  0.226676772
#> 104 -0.399334790
#> 105  4.926307341
#> 106 -0.104343146
#> 107 -0.226533604
#> 108 -0.332034077
#> 109  0.270166909
#> 110  4.846811399
#> 111 -0.457604534
#> 112  0.952494711
#> 113  0.725112891
#> 114  1.707358846
#> 115  0.694512274
#> 116 -0.537967652
#> 117  0.421792581
#> 118  0.628278599
#> 119 -0.156099574
#> 120  1.660989164
#> 121 -1.953433051
#> 122  6.548108542
#> 123  1.458397250
#> 124  2.964789707
#> 125  8.907385137
#> 126  3.295108948
#> 127  0.383000497
#> 128  0.507248038
#> 129 -3.002131221
#> 130 -0.890967339
#> 131 -1.123868110
#> 132  2.471687061
#> 133 -3.479405325
#> 134 -1.723634813
#> 135  3.051259684
#> 136 -0.009985166
#> 137  0.028904055
#> 138  0.992267033
#> 139 -0.823659996
#> 140  1.313675513
#> 141  1.322846093
#> 142 -0.825616021
#> 143 -2.350376869
#> 144 -1.507903195
#> 145 -1.593142149
#> 146 -0.525033506
#> 147 -1.668398393
#> 148 -0.343705180
#> 149  0.066193901
#> 150 -0.676033650
#> 151  1.224943263
#> 152 -1.444216259
#> 153 -0.974381638
#> 154 -0.189835075
#> 155 -0.156646459
#> 156  0.804381947
#> 157 -0.901861240
#> 158  3.816126468
#> 159  1.993831041
#> 160  1.116383733
#> 161 -3.905263193
#> 162  1.614065810
#> 163 -0.041522748
#> 164  0.083230720
#> 165 -0.839886095
#> 166 -0.256552899
#> 167 -0.609128023
#> 168 -2.688926858
#> 169  0.596565672
#> 170 -0.895150844
#> 171  0.290388790
#> 172 -0.233549329
#> 173  1.326292999
#> 174  1.042252537
#> 175 -0.705454351
#> 176 -1.942525231
#> 177 -2.052033243
#> 178 -2.806004904
#> 179 -3.699645875
#> 180  0.948954953
#> 181 -5.048493298
#> 182  4.083526647
#> 183 -0.553878555
#> 184 -5.365433454
#> 185  0.596025016
#> 186 -0.904184657
#> 187 -0.317203855
#> 188 -0.430150414
#> 189 -1.332968690
#> 190  0.177957034
#> 191  1.210428155
#> 192  0.823521467
#> 193  3.145528027
#> 194 -1.191046156
#> 195  0.718613445
#> 196 -2.812827616
#> 197 -0.586714559
#> 198 -0.762504937
#> 199 -0.103330141
#> 200 -5.817793201
#> 201 -3.378462649
#> 202 -2.431640163
#> 203 -1.574960680
#> 204 -3.842490504
#> 205 -1.183581777
#> 206  0.106951533
#> 207  1.539131248
#> 208  2.846206790
#> 209 -2.000520877
#> 210  4.189165520
#> 211 -1.569861430
#> 212 -2.164535762
#> 213 -1.491122683
#> 214  2.525756014
#> 215  0.444081456
#> 216 -1.483929487
#> 217  1.703938471
#> 218 -1.834163286
#> 219  2.348477601
#> 220  2.187488845
#> 221 -1.378583992
#> 222 -0.926222760
#> 223  0.216000833
#> 224 -2.060948988
#> 225 -1.538588309
#> 226  0.635174351
#> 227 -0.953052877
#> 228 -1.827907205
#> 229  1.330243054
#> 230 -2.384907416
#> 231 -1.070516004
#> 232 -1.914976781
#> 233  3.937922254
#> 234 -2.448939824
#> 235 -0.367377219
#> 236  0.132986261
#> 237  2.407250176
#> 238 -3.367881087
#> 239 -0.117007788
#> 240 -1.278865527
#> 241  0.017911608
#> 242  0.168080138
#> 243  2.161180951
#> 244 -1.793636673
#> 245  0.843256254
#> 246 -0.398194573
#> 247  1.250437984
#> 248 -0.079508987
#> 249  3.278707001
#> 250 -0.076167661
#> 
#> $PCs$pathway536
#>               V1
#> 1   -0.032368146
#> 2    0.808964256
#> 3    2.837758549
#> 4   -2.895052830
#> 5    2.548083603
#> 6    0.642660213
#> 7   -2.693780839
#> 8    0.643742228
#> 9   -0.603957472
#> 10  -1.095286871
#> 11   1.867137156
#> 12   2.407022119
#> 13   3.083294365
#> 14   4.479538430
#> 15  -3.630106752
#> 16  -1.359734082
#> 17  -2.850834715
#> 18  -3.839574252
#> 19  -4.755479268
#> 20   2.771943745
#> 21   0.546355316
#> 22  -2.265531140
#> 23   0.401787455
#> 24   2.880258980
#> 25   0.608504208
#> 26   1.320001613
#> 27  -0.552357914
#> 28   4.856047511
#> 29   1.909931753
#> 30   1.197391879
#> 31  -2.961713326
#> 32   0.240742052
#> 33  -0.227766729
#> 34  -3.100600979
#> 35  -3.289481515
#> 36  -1.208701914
#> 37  -5.385210146
#> 38  -0.631828936
#> 39   0.829429618
#> 40   2.290342247
#> 41   2.038322642
#> 42   0.440796705
#> 43   0.993455302
#> 44   1.849477782
#> 45  -0.823653649
#> 46   2.596966516
#> 47  -0.457142865
#> 48   2.145830814
#> 49   1.545161371
#> 50   0.375285104
#> 51  -3.442259492
#> 52  -0.013280819
#> 53   2.305808868
#> 54   0.992317632
#> 55  -1.506660636
#> 56  -1.286753242
#> 57  -1.485035573
#> 58   3.287658911
#> 59   1.294597863
#> 60  -1.588566974
#> 61   2.542915263
#> 62   1.595902095
#> 63   0.276795067
#> 64  -0.439954322
#> 65  -2.029680529
#> 66  -1.550718900
#> 67  -0.411906154
#> 68   1.485317395
#> 69  -1.017326394
#> 70  -0.650079606
#> 71   0.033813680
#> 72  -8.024254259
#> 73   0.074162506
#> 74  -0.197852580
#> 75  -1.258529555
#> 76   0.840859827
#> 77   0.049452577
#> 78  -1.640136550
#> 79  -3.992714218
#> 80   1.582002183
#> 81  -1.130124010
#> 82   2.137746660
#> 83  -3.452612879
#> 84  -2.541092428
#> 85   0.940246122
#> 86  -1.745783298
#> 87   2.606898907
#> 88   4.088805321
#> 89   2.658732085
#> 90   0.230056507
#> 91   1.123980858
#> 92   0.336410041
#> 93   2.285562060
#> 94  -3.591499859
#> 95   0.209917921
#> 96   1.778077403
#> 97  -0.962353458
#> 98  -0.432627834
#> 99   0.504111045
#> 100  1.699257081
#> 101  0.158009800
#> 102 -3.136167976
#> 103 -1.098927220
#> 104  2.221971375
#> 105 -6.250788317
#> 106  0.175575555
#> 107 -0.382708643
#> 108  0.429223358
#> 109 -0.430890742
#> 110 -6.486954104
#> 111 -0.326433942
#> 112 -1.701583073
#> 113  0.834160870
#> 114 -1.728144812
#> 115 -0.637903399
#> 116  0.115946199
#> 117  0.634305728
#> 118 -1.268626409
#> 119  1.841314054
#> 120 -1.576623018
#> 121  2.663627897
#> 122 -4.161474285
#> 123 -1.206669298
#> 124 -1.752736102
#> 125 -4.627658462
#> 126 -3.152068998
#> 127 -1.700996145
#> 128 -0.672622444
#> 129  2.689487886
#> 130  1.615703612
#> 131  2.555902393
#> 132  2.061950295
#> 133  3.495533061
#> 134  1.522775873
#> 135 -5.908122677
#> 136 -0.295737611
#> 137  1.102923740
#> 138 -3.607698254
#> 139  1.835405417
#> 140 -0.026329210
#> 141 -3.247008846
#> 142  0.952558348
#> 143  2.122787583
#> 144  1.906500249
#> 145  3.086594903
#> 146  1.603780501
#> 147  1.484881228
#> 148  1.100605030
#> 149  0.578002196
#> 150  0.915707033
#> 151 -1.478614979
#> 152  2.129988192
#> 153  2.924524034
#> 154 -0.750075216
#> 155 -0.088618831
#> 156 -0.177540434
#> 157  0.838424767
#> 158 -3.947561082
#> 159 -3.360064629
#> 160 -1.148614056
#> 161  1.949069833
#> 162 -2.004238317
#> 163  0.514781621
#> 164 -1.691973730
#> 165  0.605987486
#> 166 -1.023754436
#> 167  0.163924867
#> 168  2.364356388
#> 169 -1.118049538
#> 170  0.522201282
#> 171 -0.978505550
#> 172  0.230758506
#> 173 -1.031618130
#> 174 -2.497306502
#> 175  0.095931231
#> 176  3.143547840
#> 177  2.576879143
#> 178  2.165131795
#> 179  2.796822954
#> 180 -0.814978051
#> 181  6.209566548
#> 182 -6.509879643
#> 183 -0.365523553
#> 184  3.341005703
#> 185  0.978771175
#> 186 -1.446229581
#> 187  2.214596387
#> 188 -0.008446851
#> 189  1.275787111
#> 190  1.231113234
#> 191  0.582175011
#> 192 -1.217724027
#> 193 -5.788157049
#> 194  2.090430745
#> 195 -0.141210830
#> 196  1.954299042
#> 197  1.594614885
#> 198  2.083323740
#> 199  0.119299259
#> 200  3.228443239
#> 201  4.317932729
#> 202  2.829762235
#> 203  3.973925685
#> 204  4.483656162
#> 205 -0.736527086
#> 206 -0.287753961
#> 207 -3.021516875
#> 208 -5.455826926
#> 209  0.334994229
#> 210 -6.374648248
#> 211  3.949986870
#> 212  1.664089776
#> 213  0.514572212
#> 214 -2.292765838
#> 215 -0.912984755
#> 216  1.666302101
#> 217 -0.956197106
#> 218 -0.451556314
#> 219 -2.155676653
#> 220 -1.984818478
#> 221  0.911191805
#> 222  0.896870735
#> 223 -0.241312376
#> 224  2.259124815
#> 225  0.697401197
#> 226  0.991519774
#> 227  0.594260615
#> 228  1.110570374
#> 229 -2.177549864
#> 230  3.448303766
#> 231  0.219388322
#> 232  2.907865609
#> 233 -3.061839390
#> 234  0.106285495
#> 235  1.178869159
#> 236  1.281916185
#> 237 -4.427019475
#> 238  4.125241035
#> 239  1.554391107
#> 240  0.597113677
#> 241  0.645967899
#> 242  1.491868341
#> 243 -3.176136358
#> 244  1.955102453
#> 245  0.118745032
#> 246  0.762432052
#> 247 -3.379375221
#> 248 -1.584930956
#> 249 -5.091269595
#> 250  0.456951334
#> 
#> $PCs$pathway757
#>               V1
#> 1    0.166157467
#> 2   -1.071856878
#> 3   -2.640182401
#> 4    3.373674477
#> 5    0.980375662
#> 6    0.277150775
#> 7    2.199667712
#> 8   -0.237604704
#> 9   -0.748936415
#> 10   2.450381342
#> 11   1.229017367
#> 12  -1.156708227
#> 13  -3.737421540
#> 14  -0.185572797
#> 15   1.532197301
#> 16   0.076434916
#> 17   1.082892285
#> 18   1.884339984
#> 19   2.514030167
#> 20  -2.707823018
#> 21   0.030244189
#> 22   0.577183332
#> 23  -0.607751235
#> 24  -1.713058509
#> 25  -0.398922944
#> 26  -2.196964547
#> 27   0.725030085
#> 28  -2.607050642
#> 29   0.727440792
#> 30  -0.150511117
#> 31   2.461972789
#> 32   1.008935146
#> 33   0.592544810
#> 34   5.690491072
#> 35   1.470116540
#> 36   0.755115041
#> 37   4.278020208
#> 38  -0.748854708
#> 39  -0.885664526
#> 40  -1.059199207
#> 41  -1.394986545
#> 42  -0.563203895
#> 43   0.818147981
#> 44   1.752713465
#> 45  -0.306879280
#> 46  -1.979640000
#> 47   0.145149168
#> 48  -2.398573599
#> 49  -3.224021415
#> 50  -5.451891210
#> 51   0.604324020
#> 52   0.362923195
#> 53  -2.495198445
#> 54  -0.976234776
#> 55  -1.027579714
#> 56   1.130666378
#> 57   1.019649992
#> 58  -2.363411041
#> 59  -0.091833894
#> 60   1.133101780
#> 61  -1.314263021
#> 62  -1.200920326
#> 63   0.204543029
#> 64   0.985355354
#> 65   0.040704311
#> 66   1.027963046
#> 67  -1.533565599
#> 68  -0.170529855
#> 69   1.928837052
#> 70  -0.527586455
#> 71   0.871715140
#> 72   3.245758067
#> 73   2.318398032
#> 74  -0.003908092
#> 75   0.485658879
#> 76   0.934071737
#> 77   0.442254058
#> 78   3.578087197
#> 79   4.830766367
#> 80  -0.943178089
#> 81   0.622805665
#> 82  -0.910376760
#> 83   1.132438656
#> 84   1.129828395
#> 85  -0.411804983
#> 86   3.991206364
#> 87  -3.452392296
#> 88  -4.513161012
#> 89  -3.609593486
#> 90   1.069078008
#> 91  -2.470247108
#> 92   0.483566344
#> 93  -2.496749555
#> 94   2.441793430
#> 95   0.277150781
#> 96  -0.528867255
#> 97   2.316587429
#> 98   1.123324942
#> 99  -1.066529536
#> 100 -2.246088757
#> 101  0.048804906
#> 102  2.445858063
#> 103 -0.317458507
#> 104  0.350800345
#> 105  3.528811920
#> 106  0.173103860
#> 107 -0.463020493
#> 108 -0.317992060
#> 109  0.292891296
#> 110  3.516626474
#> 111 -1.295394487
#> 112  1.965876532
#> 113 -0.950623041
#> 114  2.402256536
#> 115  0.546158724
#> 116 -0.249848458
#> 117  1.686025806
#> 118  0.700077014
#> 119  0.444329547
#> 120  1.710059614
#> 121 -1.510981956
#> 122  8.548562968
#> 123  1.149524723
#> 124  3.701188012
#> 125 10.485842537
#> 126  4.568829950
#> 127  1.910265799
#> 128  3.303204716
#> 129 -2.120347605
#> 130 -0.166851966
#> 131 -1.132782903
#> 132  2.648452289
#> 133 -3.707010418
#> 134 -1.310928985
#> 135  2.881439252
#> 136  1.110339682
#> 137  0.728014227
#> 138  0.649910384
#> 139  0.826080179
#> 140  0.933182581
#> 141  0.366514219
#> 142 -0.199071903
#> 143 -2.029815910
#> 144 -1.010950440
#> 145 -0.680121215
#> 146 -0.574360498
#> 147 -0.810319522
#> 148 -0.606992509
#> 149 -0.741027822
#> 150  1.327569343
#> 151  2.182634465
#> 152 -0.876805082
#> 153 -1.990732460
#> 154 -1.067550489
#> 155 -0.882144189
#> 156  0.690728533
#> 157  0.290817774
#> 158  3.024752259
#> 159  3.095026132
#> 160 -0.523661198
#> 161 -3.031459082
#> 162  1.003018711
#> 163 -0.200647036
#> 164  0.214284385
#> 165 -1.188158305
#> 166  0.473992545
#> 167 -1.337030964
#> 168 -2.483069785
#> 169  0.744771786
#> 170 -0.376104405
#> 171  1.094520241
#> 172  1.223549353
#> 173  0.128270608
#> 174  0.420704243
#> 175 -0.380005348
#> 176 -3.471772966
#> 177 -0.096328626
#> 178 -2.279036461
#> 179 -2.045654416
#> 180  2.185598906
#> 181 -8.730889531
#> 182  2.122441426
#> 183 -1.725422964
#> 184 -7.970323271
#> 185 -0.576768025
#> 186  0.757569427
#> 187  1.348787740
#> 188  0.281760847
#> 189 -0.360322619
#> 190  2.268496420
#> 191  1.536699156
#> 192  0.795715254
#> 193  2.639271483
#> 194 -3.381753477
#> 195 -1.855320370
#> 196 -2.199537751
#> 197 -0.277408679
#> 198  1.262298710
#> 199 -0.230899954
#> 200 -5.119407115
#> 201 -2.296142536
#> 202 -0.721193421
#> 203 -1.397177167
#> 204 -3.475115435
#> 205 -0.033557671
#> 206 -0.401831853
#> 207  1.382604655
#> 208  1.782890868
#> 209 -1.166759801
#> 210  3.520028451
#> 211 -3.408864863
#> 212 -2.048072127
#> 213 -3.162079370
#> 214  1.241791140
#> 215 -0.238546277
#> 216 -2.571772559
#> 217  0.882211540
#> 218 -1.863975368
#> 219  1.386162400
#> 220  1.225961892
#> 221 -3.123503559
#> 222  0.532229872
#> 223  0.277757042
#> 224 -2.569804651
#> 225 -0.554857256
#> 226  0.368134113
#> 227 -1.303886248
#> 228 -0.097607336
#> 229  0.779527460
#> 230 -1.740287379
#> 231 -1.327413354
#> 232 -5.341989250
#> 233  3.511537448
#> 234 -0.156370561
#> 235  0.390618209
#> 236 -0.514673781
#> 237  3.137412813
#> 238 -6.152015237
#> 239 -1.868961185
#> 240  0.704301400
#> 241  0.782653525
#> 242  0.161831496
#> 243  0.418885026
#> 244 -1.255441349
#> 245  0.607612873
#> 246 -1.408971222
#> 247  1.536462853
#> 248 -0.047509844
#> 249  1.557101861
#> 250 -1.826215216
#> 
#> $PCs$pathway781
#>               V1
#> 1    -0.42804244
#> 2    -0.47648938
#> 3     3.23901473
#> 4    -6.80408217
#> 5    -0.88835990
#> 6    -2.17764336
#> 7    -3.36395586
#> 8     0.67055597
#> 9    -0.35579357
#> 10   -0.88389127
#> 11    1.50437760
#> 12    2.29566283
#> 13    2.62356280
#> 14    3.40113279
#> 15   -4.70278473
#> 16   -1.67206799
#> 17   -0.26470402
#> 18   -3.63995217
#> 19   -6.04721310
#> 20    4.78726327
#> 21    1.17452665
#> 22    0.52047864
#> 23   -0.82069077
#> 24    0.08371401
#> 25   -1.88643799
#> 26    1.98402347
#> 27   -0.68329615
#> 28    4.02041688
#> 29    1.56111234
#> 30    0.11441183
#> 31   -3.52084166
#> 32    1.51943628
#> 33    0.53718638
#> 34   -2.95978626
#> 35   -3.54862166
#> 36    1.04690750
#> 37   -6.67930643
#> 38    0.62555684
#> 39    2.78782681
#> 40    3.26806385
#> 41    3.52165397
#> 42    0.83697055
#> 43    2.51255321
#> 44    1.61815575
#> 45   -1.70817435
#> 46    1.10173714
#> 47   -2.84674900
#> 48    1.08458168
#> 49   -0.40982592
#> 50    5.87142495
#> 51   -3.78565266
#> 52   -1.02487499
#> 53    2.26801807
#> 54    1.37389662
#> 55   -1.10921098
#> 56   -1.44503142
#> 57   -0.35176144
#> 58    3.02524997
#> 59    1.62014295
#> 60   -3.16120654
#> 61    3.04831801
#> 62    2.68353467
#> 63   -0.02957758
#> 64    1.21720440
#> 65   -2.35438582
#> 66   -0.61739333
#> 67    0.42015319
#> 68   -0.22477270
#> 69   -3.39241385
#> 70   -0.14270300
#> 71   -0.34170774
#> 72   -8.25783489
#> 73    1.63706749
#> 74    0.53295947
#> 75   -0.84176433
#> 76    2.92406702
#> 77   -0.13639802
#> 78   -1.02626228
#> 79   -5.53580802
#> 80    1.28018932
#> 81   -3.23889806
#> 82    2.86997946
#> 83   -2.93229608
#> 84   -2.61252022
#> 85   -0.37280521
#> 86   -1.99652774
#> 87    3.88080985
#> 88    3.19196075
#> 89    2.68366799
#> 90   -0.04968742
#> 91    1.66165355
#> 92   -2.58669395
#> 93    0.69083425
#> 94   -4.31853726
#> 95    0.14325524
#> 96    3.90085763
#> 97   -0.07441426
#> 98    0.17833920
#> 99    2.75997056
#> 100   2.20536204
#> 101   0.39259779
#> 102  -3.20050100
#> 103  -0.82897705
#> 104   1.45111658
#> 105  -6.77947885
#> 106  -0.58730570
#> 107  -2.20046871
#> 108   0.53390813
#> 109   1.27123468
#> 110  -6.53523794
#> 111  -0.43251198
#> 112  -1.71222182
#> 113   1.71750736
#> 114  -1.22079694
#> 115   1.38484364
#> 116   1.08002668
#> 117   2.02716521
#> 118  -0.16666681
#> 119   2.76446689
#> 120   1.42660876
#> 121   3.77008448
#> 122  -8.25853999
#> 123  -2.68740082
#> 124  -4.50128598
#> 125 -11.48275849
#> 126  -4.62147190
#> 127   0.85415031
#> 128   0.25489561
#> 129   2.18159615
#> 130   0.52474508
#> 131   0.93408737
#> 132   1.87755128
#> 133   3.88731366
#> 134   0.86716914
#> 135  -5.71965485
#> 136  -1.56693902
#> 137  -1.50688367
#> 138  -0.93284915
#> 139   3.12840611
#> 140  -1.60262512
#> 141  -5.14557604
#> 142   0.57969011
#> 143   4.65426144
#> 144   1.58508071
#> 145   1.99033645
#> 146   3.20496522
#> 147   1.99945087
#> 148   1.18247398
#> 149  -0.16386775
#> 150   2.70364000
#> 151  -3.36368172
#> 152   2.92006079
#> 153   2.35208937
#> 154  -1.04218828
#> 155  -0.52692485
#> 156  -0.75833576
#> 157   1.36009463
#> 158  -5.95271045
#> 159  -4.71471693
#> 160   0.37866418
#> 161   1.22808851
#> 162  -1.19077423
#> 163  -0.55540378
#> 164  -1.18035415
#> 165   1.54380946
#> 166  -1.57120549
#> 167   1.01332950
#> 168   5.05609245
#> 169  -1.26746927
#> 170   1.35999412
#> 171   0.84621948
#> 172   2.03218058
#> 173  -0.39480630
#> 174  -1.37019598
#> 175   1.60911334
#> 176   1.47385010
#> 177   3.56551908
#> 178   3.89996806
#> 179   4.25804124
#> 180   1.21537224
#> 181   4.38597286
#> 182  -7.26525306
#> 183   0.15148913
#> 184   7.30935362
#> 185   2.58649642
#> 186  -0.57099814
#> 187   2.05263033
#> 188   2.06220295
#> 189   3.12426597
#> 190   1.46955552
#> 191  -1.03864677
#> 192  -2.35591478
#> 193  -5.69169924
#> 194   1.77894452
#> 195  -0.16220872
#> 196   2.11964491
#> 197  -0.39327032
#> 198   0.21530740
#> 199  -0.76086822
#> 200   6.56816315
#> 201   5.73142672
#> 202   3.92402228
#> 203   1.94683390
#> 204   3.95135735
#> 205  -0.58566604
#> 206  -0.93998014
#> 207  -2.29490117
#> 208  -6.78658578
#> 209  -0.05069081
#> 210  -5.68506916
#> 211   1.07681255
#> 212   2.56692861
#> 213   2.67499937
#> 214  -1.67120038
#> 215  -0.74752258
#> 216   1.84631173
#> 217  -0.06713446
#> 218   1.31252985
#> 219  -2.81380195
#> 220  -2.45758042
#> 221   3.42176917
#> 222   2.12238205
#> 223  -0.17555291
#> 224   2.74889280
#> 225   0.26498295
#> 226   0.66282673
#> 227   0.76785339
#> 228   1.65247634
#> 229  -2.08202424
#> 230   2.52618234
#> 231   1.90265518
#> 232   1.59529460
#> 233  -6.28454632
#> 234   1.83375651
#> 235   0.41115298
#> 236   0.82414645
#> 237  -3.63860753
#> 238   4.04422399
#> 239   0.10759389
#> 240   0.84286108
#> 241  -1.04100896
#> 242  -1.33929874
#> 243  -4.28487521
#> 244   1.87342962
#> 245  -0.48721172
#> 246   0.68014791
#> 247  -2.84614343
#> 248   0.41117851
#> 249  -4.53546749
#> 250  -0.87435149
#> 
#> $PCs$pathway1211
#>              V1
#> 1   -0.05225795
#> 2   -1.62361925
#> 3   -2.70694617
#> 4    3.12315942
#> 5    0.98022682
#> 6   -0.07084101
#> 7    1.71963136
#> 8   -0.11407197
#> 9   -0.89807061
#> 10   2.27125215
#> 11   0.93531949
#> 12  -1.71609565
#> 13  -3.94852234
#> 14  -0.54960864
#> 15   1.71317945
#> 16   0.22985634
#> 17   1.71273277
#> 18   2.38127141
#> 19   3.47737512
#> 20  -3.02665348
#> 21  -0.27664044
#> 22   0.97561562
#> 23  -0.89535254
#> 24  -2.15500919
#> 25  -0.62283518
#> 26  -2.73154994
#> 27   0.60869851
#> 28  -2.68089716
#> 29   0.46789776
#> 30  -0.58267800
#> 31   3.13650627
#> 32   0.71059143
#> 33   0.21574000
#> 34   6.06054762
#> 35   2.03720912
#> 36   1.30785916
#> 37   5.32585486
#> 38  -0.78993419
#> 39  -0.64928216
#> 40  -1.13243833
#> 41  -1.20188749
#> 42  -0.75075932
#> 43   0.39989147
#> 44   1.17635322
#> 45  -0.35347335
#> 46  -2.21116638
#> 47  -0.12918587
#> 48  -2.79097857
#> 49  -3.12238324
#> 50  -4.97754756
#> 51   1.30590687
#> 52   0.96189172
#> 53  -2.59637941
#> 54  -1.07308221
#> 55  -0.78813676
#> 56   1.18964066
#> 57   0.96623744
#> 58  -2.58317930
#> 59   0.07217414
#> 60   1.11775980
#> 61  -1.95081665
#> 62  -1.42105233
#> 63   0.19243950
#> 64   0.63376648
#> 65   0.46010356
#> 66   0.90846811
#> 67  -0.93085523
#> 68  -0.52650923
#> 69   1.54547190
#> 70  -0.52586685
#> 71   1.02131551
#> 72   5.01211498
#> 73   2.03609357
#> 74  -0.14803458
#> 75   0.42309852
#> 76   0.58640621
#> 77   0.51957877
#> 78   3.34425872
#> 79   5.14877459
#> 80  -1.49739714
#> 81   0.36005363
#> 82  -1.32732371
#> 83   1.42971247
#> 84   1.36176450
#> 85  -0.44906341
#> 86   4.55632681
#> 87  -3.14483764
#> 88  -4.57535401
#> 89  -3.05667044
#> 90   0.91513373
#> 91  -2.69815825
#> 92   0.80279838
#> 93  -2.41263684
#> 94   3.20243490
#> 95   0.49658411
#> 96  -0.77843591
#> 97   2.63209533
#> 98   1.18836802
#> 99  -1.28186558
#> 100 -2.53500042
#> 101  0.32413677
#> 102  2.48191619
#> 103 -0.34448419
#> 104  0.70656134
#> 105  4.60270811
#> 106  0.62348774
#> 107 -0.41305492
#> 108 -0.42426487
#> 109  0.19395870
#> 110  4.38582499
#> 111 -1.50086697
#> 112  1.68943034
#> 113 -1.15061339
#> 114  2.44830758
#> 115  0.54200961
#> 116 -0.33840186
#> 117  1.72196781
#> 118  0.77408195
#> 119  0.18062369
#> 120  1.79165154
#> 121 -1.80529123
#> 122  8.61296474
#> 123  0.99907030
#> 124  3.85413471
#> 125 10.45695105
#> 126  4.51494655
#> 127  1.90478013
#> 128  3.50393102
#> 129 -2.54885175
#> 130 -0.74786078
#> 131 -1.53208207
#> 132  2.24876348
#> 133 -3.98534113
#> 134 -1.63387908
#> 135  3.77226516
#> 136  0.59184995
#> 137  0.23793140
#> 138  1.16667721
#> 139  0.13248121
#> 140  0.62307963
#> 141  0.63327310
#> 142 -0.61344835
#> 143 -2.13371304
#> 144 -1.44636193
#> 145 -0.81019086
#> 146 -0.49149953
#> 147 -0.72920306
#> 148 -0.47030936
#> 149 -1.23868136
#> 150  1.12233176
#> 151  2.14977999
#> 152 -1.02028733
#> 153 -1.99080650
#> 154 -0.78118508
#> 155 -1.48002136
#> 156  0.58697823
#> 157  0.50659492
#> 158  4.17682157
#> 159  3.11324670
#> 160 -0.55262530
#> 161 -2.66988478
#> 162  1.12232473
#> 163 -0.19147086
#> 164  0.44917023
#> 165 -1.20516517
#> 166  0.59080427
#> 167 -1.51383331
#> 168 -2.91152842
#> 169  0.41888429
#> 170 -0.49690665
#> 171  1.10179166
#> 172  1.23597517
#> 173  0.76733754
#> 174  0.71900792
#> 175 -0.43777241
#> 176 -3.70541773
#> 177 -0.28082880
#> 178 -2.06498494
#> 179 -2.41992628
#> 180  2.36630321
#> 181 -8.14196697
#> 182  3.11864591
#> 183 -1.76118601
#> 184 -7.16460914
#> 185 -0.65479333
#> 186  0.50000550
#> 187  1.40932038
#> 188  0.47054597
#> 189 -0.42574382
#> 190  2.13382058
#> 191  1.41589976
#> 192  0.87533843
#> 193  3.57110596
#> 194 -3.71348632
#> 195 -1.73016427
#> 196 -2.86125546
#> 197 -0.98135843
#> 198  0.81566171
#> 199 -0.35101545
#> 200 -5.52256446
#> 201 -2.49044637
#> 202 -1.19371580
#> 203 -1.82388360
#> 204 -3.40024210
#> 205  0.14724561
#> 206 -0.73930115
#> 207  2.00743999
#> 208  2.25141823
#> 209 -1.12799219
#> 210  4.30532171
#> 211 -3.41859395
#> 212 -2.11349841
#> 213 -2.75621237
#> 214  1.48276540
#> 215 -0.38643536
#> 216 -2.55682836
#> 217  0.69214441
#> 218 -1.62188343
#> 219  1.45346211
#> 220  1.70075056
#> 221 -3.04609437
#> 222  0.35121988
#> 223  0.02899325
#> 224 -2.70930943
#> 225 -0.63304141
#> 226  0.16845679
#> 227 -1.63923384
#> 228 -0.37494349
#> 229  0.98493031
#> 230 -1.92102258
#> 231 -1.25545892
#> 232 -5.26018904
#> 233  3.47963833
#> 234 -0.43718473
#> 235  0.46190826
#> 236 -0.81185541
#> 237  3.49809291
#> 238 -6.33788189
#> 239 -2.41889882
#> 240  0.46174163
#> 241  1.23356423
#> 242 -0.21361956
#> 243  1.20743703
#> 244 -1.56805350
#> 245  0.34573262
#> 246 -1.08023168
#> 247  1.74629501
#> 248  0.07422190
#> 249  1.90231793
#> 250 -2.01352084
#> 
#> 
#> $loadings
#> $loadings$pathway3
#>                PC1
#> RPE     0.00000000
#> RPIA    0.08309642
#> PGM2    0.18474584
#> PGLS    0.23558646
#> PRPS2   0.00000000
#> FBP2    0.00000000
#> PFKM    0.19010770
#> PFKL    0.31980488
#> TALDO1  0.34171100
#> TKT     0.42332220
#> FBP1    0.00000000
#> TKTL2   0.00000000
#> PGD     0.23115869
#> RBKS    0.00000000
#> ALDOA   0.34407531
#> ALDOC   0.18585710
#> ALDOB   0.00000000
#> H6PD    0.00000000
#> PRPS1L1 0.00000000
#> PRPS1   0.00000000
#> DERA    0.00000000
#> G6PD    0.20203832
#> PGM1    0.00000000
#> TKTL1   0.00000000
#> PFKP    0.17788494
#> GPI     0.43617798
#> 
#> $loadings$pathway60
#>                PC1
#> RPE65   0.00000000
#> CYP3A5  0.00000000
#> UGT2B28 0.00000000
#> CYP4A11 0.42561460
#> CYP3A4  0.00000000
#> RDH8    0.00000000
#> DHRS3   0.00000000
#> CYP2C18 0.00000000
#> ADH1B   0.00000000
#> ADH1C   0.00000000
#> ADH4    0.00000000
#> ADH5    0.00000000
#> DGAT2   0.00000000
#> ADH1A   0.14458111
#> RDH10   0.00000000
#> CYP26A1 0.00000000
#> CYP2C9  0.47180005
#> CYP2C19 0.20161821
#> CYP2C8  0.28175565
#> CYP2B6  0.00000000
#> UGT2A3  0.00000000
#> CYP2A13 0.28300001
#> UGT1A1  0.00000000
#> CYP26B1 0.00000000
#> DHRS9   0.00000000
#> DGAT1   0.00000000
#> ALDH1A1 0.00000000
#> RETSAT  0.00000000
#> RDH12   0.15555054
#> LRAT    0.00000000
#> RDH11   0.00000000
#> CYP2A6  0.29656870
#> CYP2A7  0.09609107
#> CYP1A1  0.18101488
#> CYP1A2  0.11302901
#> ADH7    0.00000000
#> ADH6    0.00000000
#> ALDH1A2 0.12513411
#> CYP3A43 0.22129773
#> RDH16   0.33765806
#> RDH5    0.15171910
#> PNPLA4  0.00000000
#> UGT2B4  0.00000000
#> UGT2B17 0.00000000
#> UGT2B15 0.08149112
#> 
#> $loadings$pathway87
#>                  PC1
#> JUN       0.00000000
#> SOS2      0.42312485
#> PAK3     -0.32935094
#> RAF1      0.00000000
#> PRKCB     0.00000000
#> BTC       0.00000000
#> SHC1      0.00000000
#> PRKCA     0.00000000
#> ELK1     -0.08623293
#> NRG1      0.00000000
#> PAK2      0.24625157
#> MTOR      0.00000000
#> PAK4     -0.21278260
#> MAP2K4    0.00000000
#> EIF4EBP1  0.00000000
#> BAD       0.00000000
#> PRKCG    -0.26353046
#> NRG3      0.00000000
#> MAPK9     0.00000000
#> ERBB4     0.00000000
#> MAPK10    0.00000000
#> PTK2      0.00000000
#> ERBB2     0.00000000
#> ERBB3     0.00000000
#> MAP2K2    0.00000000
#> TGFA      0.00000000
#> BRAF      0.00000000
#> MAP2K1    0.00000000
#> MAP2K7    0.00000000
#> ABL1      0.00000000
#> NRG2     -0.16901494
#> AKT1      0.00000000
#> ABL2      0.00000000
#> AKT2      0.00000000
#> SHC4      0.00000000
#> RPS6KB1   0.15182995
#> RPS6KB2   0.00000000
#> AKT3      0.00000000
#> NRAS      0.06718666
#> GRB2      0.00000000
#> AREG      0.00000000
#> STAT5B    0.14022707
#> MAPK3     0.00000000
#> STAT5A    0.00000000
#> PAK6      0.00000000
#> SOS1      0.00000000
#> MYC       0.00000000
#> MAPK1     0.31687486
#> NCK1      0.00000000
#> PIK3R5    0.00000000
#> NRG4     -0.02572517
#> HRAS      0.00000000
#> MAPK8     0.00000000
#> EGFR      0.00000000
#> GSK3B     0.19717758
#> CBLB      0.19594255
#> KRAS      0.00000000
#> CBL       0.00000000
#> SHC3      0.00000000
#> CDKN1B    0.00000000
#> CDKN1A    0.00000000
#> EGF       0.00000000
#> EREG      0.00000000
#> ARAF      0.00000000
#> NCK2      0.00000000
#> SRC       0.00000000
#> PIK3R3    0.00000000
#> CAMK2A   -0.22020866
#> CAMK2B   -0.44294565
#> CAMK2D    0.00000000
#> CAMK2G    0.00000000
#> PAK1      0.00000000
#> CBLC      0.00000000
#> CRK       0.00000000
#> PIK3CA    0.17566992
#> PIK3CB    0.00000000
#> CRKL      0.00000000
#> PIK3CD    0.00000000
#> GAB1      0.00000000
#> PLCG1     0.00000000
#> PLCG2     0.00000000
#> SHC2      0.00000000
#> HBEGF     0.00000000
#> PIK3CG    0.00000000
#> PIK3R1    0.00000000
#> PIK3R2    0.00000000
#> 
#> $loadings$pathway120
#>                 PC1
#> HLA-DOA  0.27650582
#> HLA-DOB  0.00000000
#> KLRC3    0.00000000
#> KLRD1    0.27344491
#> RFXAP    0.00000000
#> RFX5     0.00000000
#> IFNA5    0.00000000
#> IFNA4    0.00000000
#> IFNA2    0.00000000
#> IFNA1    0.00000000
#> LGMN     0.09980320
#> PSME3    0.00000000
#> CTSS     0.00000000
#> HLA-C    0.30928167
#> HLA-B    0.00000000
#> HLA-DMB  0.46738428
#> HLA-DMA  0.30600315
#> HLA-A    0.00000000
#> HSPA1L   0.00000000
#> HSPA2    0.00000000
#> KIR2DS5  0.00000000
#> HLA-G    0.26045105
#> KIR3DL1  0.00000000
#> RFXANK   0.00000000
#> CREB1    0.00000000
#> IFNA17   0.00000000
#> HSPA5    0.00000000
#> CD74     0.37444858
#> HSPA4    0.00000000
#> IFNA21   0.00000000
#> IFNA7    0.00000000
#> IFNA8    0.00000000
#> IFNA10   0.00000000
#> CIITA    0.00000000
#> IFNA14   0.00000000
#> IFNA16   0.00000000
#> KIR2DL5A 0.00000000
#> HSPA6    0.00000000
#> HLA-DRB4 0.00000000
#> CD4      0.12822158
#> KIR2DL1  0.00000000
#> LTA      0.00000000
#> KIR3DL3  0.00000000
#> TAP2     0.00000000
#> KIR2DS4  0.00000000
#> TAPBP    0.00000000
#> CD8A     0.24137396
#> CD8B     0.00000000
#> TAP1     0.25158248
#> KIR2DS3  0.00000000
#> KIR2DL4  0.00000000
#> CANX     0.00000000
#> KIR2DS1  0.00000000
#> KIR2DL2  0.00000000
#> KIR2DL3  0.00000000
#> KLRC4    0.07882354
#> NFYC     0.00000000
#> HSP90AA1 0.00000000
#> NFYA     0.00000000
#> NFYB     0.00000000
#> HLA-F    0.09359384
#> CTSB     0.00000000
#> HLA-E    0.14101548
#> CALR     0.00000000
#> HLA-DPA1 0.09893340
#> HLA-DPB1 0.00000000
#> HLA-DQA1 0.00000000
#> PDIA3    0.00000000
#> HLA-DQB1 0.00000000
#> PSME1    0.14315672
#> HSP90AB1 0.00000000
#> B2M      0.00000000
#> HLA-DRA  0.14102552
#> 
#> $loadings$pathway176
#>                PC1
#> CASP9   0.00000000
#> SOS2    0.38078250
#> E2F1    0.00000000
#> PRKCB   0.00000000
#> RAF1    0.00000000
#> PRKCA   0.00000000
#> RARB    0.00000000
#> BAD     0.00000000
#> PRKCG  -0.24341476
#> ERBB2   0.06693903
#> MAP2K2  0.19173352
#> TGFA    0.00000000
#> BRAF    0.00000000
#> MAP2K1  0.00000000
#> RXRB    0.39316520
#> PDPK1   0.00000000
#> RXRG    0.00000000
#> RB1     0.32528114
#> RXRA    0.00000000
#> RASSF1  0.00000000
#> AKT1    0.00000000
#> AKT2    0.00000000
#> NRAS    0.31147241
#> AKT3    0.00000000
#> GRB2    0.00000000
#> MAPK3   0.00000000
#> SOS1    0.00000000
#> MAPK1   0.43491764
#> PIK3R5  0.00000000
#> HRAS    0.00000000
#> EGFR   -0.13874373
#> KRAS    0.00000000
#> CDKN2A  0.00000000
#> EGF     0.00000000
#> RASSF5  0.00000000
#> FHIT    0.00000000
#> STK4    0.13369802
#> ARAF    0.00000000
#> CCND1   0.00000000
#> PIK3R3  0.00000000
#> FOXO3   0.00000000
#> CDK4    0.00000000
#> TP53    0.00000000
#> E2F3    0.00000000
#> E2F2   -0.04198616
#> PIK3CA  0.08291277
#> PIK3CB  0.25493014
#> CDK6    0.26327445
#> PIK3CD  0.00000000
#> PLCG1   0.00000000
#> PLCG2   0.00000000
#> PIK3CG  0.00000000
#> PIK3R1  0.16700629
#> PIK3R2  0.00000000
#> 
#> $loadings$pathway177
#>                PC1
#> HLA-DRB4 0.0000000
#> HLA-DOA  0.2254690
#> HLA-DOB  0.1197166
#> IL3      0.0000000
#> TNF      0.0000000
#> CCL11    0.0000000
#> EPX      0.0000000
#> FCER1G   0.3216311
#> MS4A2    0.0331045
#> HLA-DMB  0.3455215
#> FCER1A   0.0000000
#> HLA-DMA  0.2633184
#> IL9      0.0000000
#> CD40LG   0.0000000
#> HLA-DPA1 0.3633717
#> CD40     0.1677582
#> HLA-DPB1 0.4630354
#> IL13     0.0000000
#> HLA-DQA1 0.1404418
#> HLA-DQB1 0.0000000
#> PRG2     0.0000000
#> RNASE3   0.0000000
#> IL4      0.0000000
#> IL5      0.0000000
#> IL10     0.2508474
#> HLA-DRA  0.4293432
#> 
#> $loadings$pathway187
#>                 PC1
#> IKBKG     0.0000000
#> CHUK      0.2809446
#> EP300     0.1802670
#> RELA      0.0000000
#> TNF      -0.4364239
#> IKBKB    -0.1668258
#> TNFRSF1B -0.3074535
#> HDAC3     0.0000000
#> TNFRSF1A -0.3996441
#> TRAF6    -0.1565584
#> FADD      0.0000000
#> CREBBP    0.0000000
#> RIPK1     0.1286944
#> NFKB1     0.0000000
#> NFKBIA   -0.5204295
#> TRADD    -0.3226679
#> 
#> $loadings$pathway266
#>               PC1
#> PRF1    0.3773644
#> DFFA    0.0000000
#> DFFB    0.3963384
#> HMGB2   0.3720807
#> NME1    0.3285096
#> APEX1   0.1883684
#> GZMB    0.3272256
#> CREBBP -0.2078295
#> SET    -0.2940905
#> GZMA    0.3418805
#> ANP32A  0.2550010
#> 
#> $loadings$pathway390
#>                  PC1
#> JUN       0.14667960
#> BAG4      0.00000000
#> CASP8    -0.32973828
#> MAPK8     0.00000000
#> TNF       0.00000000
#> PAK2     -0.38201363
#> LMNA     -0.13986564
#> SPTAN1    0.22497882
#> LMNB1    -0.18571699
#> CRADD    -0.10476180
#> MAP2K4   -0.12982222
#> TRAF2     0.00000000
#> FADD     -0.07048063
#> RIPK1    -0.38542686
#> TRADD     0.19004356
#> LMNB2    -0.06719776
#> MADD      0.10593220
#> MAP3K1   -0.33085258
#> PAK1      0.00000000
#> MAP3K7    0.00000000
#> RB1      -0.30502593
#> CASP3    -0.16017572
#> TNFRSF1A  0.00000000
#> CASP2    -0.27107623
#> DFFA      0.00000000
#> DFFB     -0.19240550
#> ARHGDIB  -0.17617497
#> PRKDC     0.00000000
#> PARP1    -0.12747706
#> 
#> $loadings$pathway413
#>                PC1
#> PLD1    0.46173570
#> RAF1   -0.06480465
#> EPHB2   0.00000000
#> VAV1    0.00000000
#> PTK2    0.00000000
#> F2RL2   0.00000000
#> MAPK7  -0.20969846
#> BTK     0.00000000
#> JUN     0.00000000
#> PLD3    0.00000000
#> CFB     0.00000000
#> F2RL3   0.00000000
#> F2     -0.17911978
#> DLG4    0.00000000
#> MYEF2   0.00000000
#> PLD2    0.00000000
#> RASAL1  0.00000000
#> NR4A3  -0.16012161
#> SRC     0.29898309
#> MAPK1   0.57606993
#> MAP2K5  0.00000000
#> MAPK8   0.00000000
#> F2RL1   0.50956529
#> 
#> $loadings$pathway491
#>                PC1
#> EPHB2   0.15805668
#> EPHB4   0.13210581
#> EFNA5   0.00000000
#> MAPK1  -0.39827477
#> SRC     0.00000000
#> GRB2    0.00000000
#> MAP2K1  0.00000000
#> PXN     0.00000000
#> CRK     0.00000000
#> CDC42   0.00000000
#> HRAS    0.00000000
#> NCK1   -0.18137663
#> KRAS    0.00000000
#> EFNB3   0.00000000
#> RRAS    0.00000000
#> PAK1    0.00000000
#> MAPK3   0.00000000
#> GRB7    0.00000000
#> PTK2    0.00000000
#> SYNJ1  -0.23821550
#> EPHB3   0.00000000
#> EFNB1   0.00000000
#> DNM1    0.00000000
#> MAP4K4 -0.46973988
#> PIK3CA -0.36422160
#> GRIA1   0.00000000
#> EPHB1   0.00000000
#> ROCK1  -0.14583745
#> NRAS   -0.18962976
#> ITSN1  -0.45176135
#> RAP1A   0.00000000
#> RAC1    0.00000000
#> RAP1B  -0.22739251
#> EFNB2   0.00000000
#> PIK3R1 -0.07568222
#> SHC1   -0.15903428
#> WASL    0.00000000
#> TF      0.00000000
#> KALRN   0.00000000
#> RASA1  -0.10928375
#> 
#> $loadings$pathway536
#>                  PC1
#> TNF       0.00000000
#> MAP4K5    0.39021067
#> SMPD1     0.00000000
#> BAG4      0.00000000
#> TRAF1     0.00000000
#> RFFL     -0.16922944
#> NFKB1     0.00000000
#> STAT1     0.00000000
#> NSMAF     0.18347938
#> MAP3K5    0.00000000
#> TRADD    -0.11777630
#> TAB2      0.45899060
#> IKBKB     0.00000000
#> PRKCZ    -0.24725446
#> TNFAIP3   0.07637776
#> MAP4K4    0.29731749
#> TRAF2     0.00000000
#> RIPK1     0.25911893
#> CAV1      0.14610940
#> MAP3K3    0.00000000
#> PRKCI     0.26525627
#> BIRC3     0.00000000
#> IKBKG     0.00000000
#> CASP8     0.00000000
#> CHUK      0.00000000
#> FADD      0.00000000
#> MAP3K7    0.00000000
#> TXN       0.00000000
#> SQSTM1    0.00000000
#> MAP3K1    0.31384218
#> MAP4K3    0.08991182
#> MAP4K2    0.00000000
#> SMPD2    -0.11376310
#> TAB1      0.00000000
#> TNIK      0.12142424
#> NRK       0.00000000
#> MADD     -0.10875614
#> MAP2K7    0.00000000
#> RELA      0.00000000
#> ADAM17    0.15920438
#> TNFRSF1B  0.00000000
#> CYLD      0.27428153
#> TNFRSF1A  0.00000000
#> BIRC2     0.00000000
#> 
#> $loadings$pathway757
#>                  PC1
#> FRS2      0.00000000
#> THEM4     0.00000000
#> CRK       0.00000000
#> KLB       0.00000000
#> DOK1      0.00000000
#> EIF4B     0.00000000
#> EIF4E     0.00000000
#> EIF4EBP1  0.22383288
#> EIF4G1    0.00000000
#> AKT2      0.00000000
#> FGF1     -0.04186531
#> FGF2     -0.06825230
#> FGF3      0.00000000
#> FGF4      0.04612668
#> FGF5      0.00000000
#> FGF6      0.47517687
#> FGF7     -0.18889229
#> FGF8      0.00000000
#> FGF9      0.00000000
#> FGF10     0.00000000
#> FGFR1    -0.08707312
#> FGFR3     0.00000000
#> FGFR2     0.00000000
#> FGFR4     0.00000000
#> MTOR      0.00000000
#> GAB1     -0.11919406
#> SHC2      0.00000000
#> FGF20     0.00000000
#> FGF22     0.23740372
#> GRB2      0.00000000
#> GRB10     0.00000000
#> PIK3R4    0.00000000
#> HRAS      0.00000000
#> INS       0.00000000
#> INSR      0.00000000
#> IRS1      0.00000000
#> KRAS      0.00000000
#> NRAS      0.00000000
#> PDE3B     0.00000000
#> PRKAG2    0.00000000
#> PDPK1     0.00000000
#> CAB39    -0.29522785
#> PIK3C3   -0.18125395
#> PIK3CA   -0.41174161
#> PIK3CB    0.00000000
#> PIK3R1   -0.09528909
#> PIK3R2    0.00000000
#> SHC3      0.00000000
#> PRKAG3    0.00000000
#> TLR9      0.00000000
#> PPM1A     0.00000000
#> STRADB    0.00000000
#> PRKAA1    0.00000000
#> PRKAA2    0.00000000
#> PRKAB1    0.00000000
#> PRKAB2   -0.19246008
#> PRKAG1    0.00000000
#> MAPK1     0.00000000
#> MAPK3     0.00000000
#> MAP2K1    0.00000000
#> MAP2K2    0.00000000
#> RPTOR     0.00000000
#> TRIB3     0.00000000
#> RAF1      0.00000000
#> RHEB      0.00000000
#> RPS6      0.04577916
#> RPS6KB1   0.00000000
#> MLST8     0.11586256
#> SHC1      0.00000000
#> SOS1      0.00000000
#> STK11     0.19494480
#> TSC1      0.00000000
#> TSC2      0.00000000
#> YWHAB     0.00000000
#> FGF23     0.37499442
#> CAB39L    0.00000000
#> IRS2      0.00000000
#> FGF18     0.00000000
#> FGF17     0.26819502
#> STRADA    0.00000000
#> KL        0.00000000
#> CDK1      0.00000000
#> FGF19     0.00000000
#> 
#> $loadings$pathway781
#>                  PC1
#> COL4A3BP  0.18117372
#> LPCAT3    0.00000000
#> CEPT1     0.00000000
#> CDS1      0.00000000
#> PEMT      0.00000000
#> CDIPT     0.00000000
#> AGPAT1    0.00000000
#> AGPAT2    0.00000000
#> SPTLC1    0.00000000
#> NEU3      0.00000000
#> CHAT      0.00000000
#> PLA2G16   0.00000000
#> CHKA      0.00000000
#> CHKB      0.00000000
#> MGLL      0.00000000
#> PLD4      0.00000000
#> DEGS2     0.00000000
#> ACER1     0.00000000
#> SLC44A3   0.00000000
#> MBOAT2    0.00000000
#> NEU4      0.00000000
#> SGPP2     0.00000000
#> CSNK1G2   0.00000000
#> PIK3R6    0.00000000
#> GPAT2     0.00000000
#> PPM1L     0.00000000
#> ARSK      0.00000000
#> MBOAT1    0.00000000
#> PHOSPHO1  0.00000000
#> SGMS2     0.05578761
#> PIKFYVE   0.00000000
#> PLD6      0.00000000
#> CERS3     0.00000000
#> SLC44A5   0.00000000
#> ARSG     -0.22408551
#> SACM1L    0.00000000
#> GPD1L     0.00000000
#> LPIN1     0.00000000
#> PIP5K1C   0.00000000
#> SLC44A1   0.05117438
#> PIK3R5    0.00000000
#> PLD3      0.00000000
#> PITPNB    0.00000000
#> KDSR      0.15694451
#> LCLAT1    0.00000000
#> CERS6     0.00000000
#> LPCAT4    0.00000000
#> PLA2G4F   0.00000000
#> GALC      0.00000000
#> SUMF2     0.00000000
#> SGMS1     0.15697800
#> PLA2G2D   0.00000000
#> INPP5J   -0.14397275
#> GLA       0.00000000
#> GM2A      0.12050570
#> GPD1      0.00000000
#> PLA2G4D   0.00000000
#> SUMF1     0.00000000
#> CERS2     0.00000000
#> HADHA     0.00000000
#> HADHB     0.00000000
#> HEXA      0.00000000
#> HEXB      0.00000000
#> PLA2G2E   0.00000000
#> PIK3R4    0.00000000
#> ENPP7     0.00000000
#> ARSI      0.00000000
#> INPPL1    0.00000000
#> ARF1      0.00000000
#> ARF3      0.00000000
#> ARSA      0.00000000
#> ARSB      0.37448747
#> STS       0.10611074
#> ARSE      0.00000000
#> ARSF     -0.03715607
#> ASAH1     0.00000000
#> ACHE      0.00000000
#> MTM1      0.00000000
#> NEU1      0.00000000
#> NEU2      0.00000000
#> OCRL      0.00000000
#> OSBP      0.00000000
#> PLA2G3    0.00000000
#> PNPLA8    0.00000000
#> PCYT1A    0.00000000
#> INPP5K    0.00000000
#> PIK3C2A   0.23360555
#> PIK3C2B   0.00000000
#> PIK3C2G   0.00000000
#> PIK3C3    0.00000000
#> PIK3CA    0.12006744
#> PIK3CB    0.00000000
#> PIK3CD    0.00000000
#> PIK3CG    0.00000000
#> PIK3R1    0.00000000
#> PIK3R2   -0.13454869
#> PI4KA     0.00000000
#> PI4KB     0.00000000
#> PIP4K2A   0.00000000
#> PLA2G1B   0.00000000
#> PLA2G2A   0.00000000
#> PLA2G4A   0.05776150
#> PLA2G5    0.00000000
#> PLD1      0.12457058
#> PLD2     -0.08101479
#> CRLS1     0.00000000
#> CTSA      0.00000000
#> LPCAT2    0.00000000
#> ETNK2     0.00000000
#> AGPAT5    0.00000000
#> ACER3     0.00000000
#> PI4K2A    0.00000000
#> ETNK1     0.00000000
#> SMPD3     0.00000000
#> VAC14     0.00000000
#> PRKD1     0.00000000
#> GPCPD1    0.00000000
#> PSAP      0.00000000
#> INPP5E   -0.05190249
#> SPHK2     0.00000000
#> AGPAT3    0.00000000
#> AGPAT4    0.16970877
#> CHPT1     0.00000000
#> PNPLA2   -0.13089790
#> SLC44A2   0.00000000
#> PTEN      0.04838670
#> GPAM      0.00000000
#> GBA2      0.00000000
#> GBA3      0.00000000
#> PCYT2     0.00000000
#> MTMR14    0.00000000
#> PLA2G2F   0.00000000
#> CERK      0.00000000
#> LPIN3     0.00000000
#> SMPD1     0.00000000
#> SMPD2     0.00000000
#> TAZ      -0.15173724
#> UGCG      0.29995353
#> MBOAT7    0.00000000
#> CERS4     0.00000000
#> ARSJ      0.00000000
#> PLBD1     0.00000000
#> LPCAT1    0.00000000
#> PNPLA3    0.00000000
#> SLC44A4   0.00000000
#> PTDSS2    0.00000000
#> SGPP1     0.34023617
#> PLA2G12A  0.00000000
#> PIP5K1B   0.00000000
#> PIP4K2B   0.00000000
#> PLA2G6   -0.07647503
#> GNPAT     0.00000000
#> DGAT2     0.00000000
#> PIK3R3    0.00000000
#> DEGS1     0.00000000
#> PLA2G4C   0.00000000
#> DGAT1     0.00000000
#> CDS2      0.00000000
#> MTMR1     0.00000000
#> INPP4B    0.00000000
#> SYNJ1     0.28929351
#> SYNJ2     0.00000000
#> SPHK1     0.00000000
#> SGPL1     0.00000000
#> MTMR3     0.00000000
#> MTMR2     0.41473912
#> CERS5     0.00000000
#> MTMR6     0.00000000
#> MTMR7     0.00000000
#> MTMR4     0.00000000
#> VAPB      0.00000000
#> VAPA      0.05196021
#> PCYT1B    0.00000000
#> PGS1      0.00000000
#> GAL3ST1   0.00000000
#> SPTLC2    0.13169134
#> LPIN2     0.00000000
#> PTDSS1    0.00000000
#> FIG4      0.00000000
#> LPGAT1    0.00000000
#> 
#> $loadings$pathway1211
#>                  PC1
#> TCIRG1    0.00000000
#> FRS2      0.00000000
#> THEM4     0.00000000
#> ATP6V1G3  0.00000000
#> CRK       0.00000000
#> KLB       0.00000000
#> DOK1      0.09677647
#> EIF4B     0.00000000
#> EIF4E     0.00000000
#> EIF4EBP1  0.21559938
#> EIF4G1    0.00000000
#> AKT2      0.00000000
#> FGF1      0.00000000
#> FGF2     -0.04557154
#> FGF3      0.00000000
#> FGF4      0.04419912
#> FGF5      0.07045668
#> FGF6      0.42251270
#> FGF7     -0.20139867
#> FGF8      0.00000000
#> FGF9      0.00000000
#> FGF10     0.00000000
#> FGFR1    -0.04157605
#> FGFR3     0.00000000
#> FGFR2     0.00000000
#> FGFR4     0.00000000
#> ATP6V0A2  0.00000000
#> ATP6V0D2  0.00000000
#> ATP6V1C2  0.00000000
#> MTOR      0.00000000
#> GAB1     -0.12236499
#> SHC2      0.00000000
#> FGF20     0.00000000
#> FGF22     0.24936623
#> GRB2      0.00000000
#> GRB10     0.00000000
#> PIK3R4    0.00000000
#> HRAS      0.00000000
#> INS       0.00000000
#> INSR      0.00000000
#> IRS1      0.00000000
#> KRAS      0.00000000
#> NRAS      0.00000000
#> ATP6V0A4  0.00000000
#> ATP6V1D   0.00000000
#> PDE3B     0.00000000
#> PRKAG2    0.00000000
#> ATP6V1H   0.00000000
#> PDPK1     0.00000000
#> CAB39    -0.45282840
#> ATP6V1A  -0.10168028
#> ATP6V1B1  0.00000000
#> ATP6V1B2  0.00000000
#> ATP6V0C   0.00000000
#> ATP6V1C1 -0.03977924
#> PIK3C3   -0.18353359
#> ATP6V1E1  0.00000000
#> PIK3CA   -0.38153329
#> PIK3CB    0.00000000
#> PIK3R1   -0.11609819
#> PIK3R2    0.00000000
#> ATP6V0B   0.00000000
#> SHC3      0.00000000
#> ATP6V1G2  0.00000000
#> PRKAG3    0.00000000
#> TLR9      0.00000000
#> PPM1A     0.00000000
#> STRADB    0.00000000
#> PRKAA1    0.00000000
#> PRKAA2    0.00000000
#> PRKAB1    0.00000000
#> PRKAB2   -0.16691763
#> PRKAG1    0.00000000
#> MAPK1    -0.07542557
#> MAPK3     0.00000000
#> MAP2K1    0.00000000
#> MAP2K2    0.00000000
#> RPTOR     0.00000000
#> TRIB3     0.00000000
#> RAF1      0.00000000
#> RHEB      0.00000000
#> RPS6      0.03872690
#> RPS6KB1   0.00000000
#> MLST8     0.16408684
#> SHC1      0.00000000
#> SOS1      0.00000000
#> STK11     0.13299393
#> TSC1      0.00000000
#> TSC2      0.00000000
#> YWHAB     0.00000000
#> FGF23     0.29596110
#> CAB39L    0.00000000
#> IRS2      0.00000000
#> FGF18     0.00000000
#> FGF17     0.23938705
#> ATP6V0E1  0.00000000
#> ATP6V1E2  0.00000000
#> ATP6V0D1  0.00000000
#> STRADA    0.05409184
#> ATP6V1F   0.00000000
#> KL        0.00000000
#> ATP6V1G1  0.00000000
#> CDK1      0.00000000
#> FGF19     0.00000000
#> 
#>